Compartment syndrome: A quantitative study of high-energy phosphorus compounds using sup 31 P-magnetic resonance spectroscopy

Journal Article · Tue Aug 01 00:00:00 EDT 1989 · Journal of Trauma; (USA)

DOI:https://doi.org/10.1097/00005373-198908000-00008· OSTI ID:5669624

Heppenstall, R B; Sapega, A A; Izant, T; Fallon, R; Shenton, D; Park, Y S; Chance, B ^[1]

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1. Veterans Administration Medical Center, Philadelphia, PA (USA)

The purpose of this study was to quantitate the intracellular high-energy phosphate compounds during 6 hours of tissue ischemia in the anterior tibial compartment of beagles subjected to an induced traumatized compartment syndrome. The goal of this work was to provide clinicians with objective criteria to augment clinical judgment regarding surgical intervention in the impending compartment syndrome. A beagle model was utilized in which the Delta pressure (difference between the mean arterial pressure and compartment pressure) could be controlled. The model, in conjunction with {sup 31}P-magnetic resonance spectroscopy (MRS), allowed a measure of high-energy phosphate compounds and pH in the compartment at various Delta pressures. The extent of ischemic metabolic insult in the compartment was then quantitated. Our data suggest the following: (1) lower Delta pressures result in a proportionally greater drop in the intracellular phosphocreatine ratio and pH; (2) at lower Delta pressures, there is proportionally greater decline in the percentage recovery post-fasciotomy; (3) blood pressure is extremely important and periods of hypotension may result in increased muscle damage at lower compartment pressures.

• OSTI ID: 5669624
• Journal Information: Journal of Trauma; (USA), Vol. 29:8; ISSN 0022-5282
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ISCHEMIA
PATHOGENESIS
PHOSPHORUS COMPOUNDS
NMR SPECTRA
BEAGLES
BIOLOGICAL MODELS
BLOOD PRESSURE
ELECTRON MICROSCOPY
METABOLISM
MUSCLES
NUCLEAR MAGNETIC RESONANCE
PHOSPHORUS 31
TRACER TECHNIQUES
ANIMALS
CARDIOVASCULAR DISEASES
DISEASES
DOGS
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
MAMMALS
MICROSCOPY
NUCLEI
ODD-EVEN NUCLEI
PHOSPHORUS ISOTOPES
RESONANCE
SPECTRA
STABLE ISOTOPES
VASCULAR DISEASES
VERTEBRATES
550901* - Pathology- Tracer Techniques