skip to main content

Title: Chromosome instability syndromes

Chapter 11, discusses chromosome instability syndromes. The focus is on the most extensively studied genotypic chromosomal aberrations which include Bloom syndrome, Fanconi anemia, ataxia telangiectasia, and xeroderma pigmentosum. The great interest in these syndromes is out of proportion to their rare occurrence; however, studies of genotypic chromosome breakage have been inspired by the hope of throwing light on chromosome structure and behavior. A table is given which relates chromosomal aberrations in Bloom syndrome which may cause or promote cancer. 34 refs., 3 figs., 1 tab.
Publication Date:
OSTI Identifier:
56695
Resource Type:
Book
Resource Relation:
Other Information: PBD: 1993; Related Information: Is Part Of Human chromosomes: Structure, behavior, and effects; Therman, E.; Susman, M.; PB: 393 p.
Publisher:
Springer-Verlag, New York, NY (United States)
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; HUMAN CHROMOSOMES; CHROMOSOMAL ABERRATIONS; CHROMOSOME BREAKAGE; SOMATIC MUTATIONS; HUMAN POPULATIONS; GENOTYPE; HEREDITARY DISEASES; NEOPLASMS; SISTER CHROMATID EXCHANGES; GENETIC MAPPING