Age differences in plasma norepinephrine kinetics in humans
Abstract
To determine if the increased plasma norepinephrine (NE) of older individuals is due to greater plasma NE appearance rate and/or decreased NE clearance, arterialized plasma NE kinetics were measured in 25 healthy young (27 +/- 6 yr, M +/- SD) and 18 healthy older volunteers (68 +/- 5 yr) using a tritium-labeled NE isotope dilution technique. Basal NE levels were 54% greater in the older participants (282 +/- 24 vs. 183 +/- 11 pg/ml, M +/- SEM, p less than .001). The mean plasma NE appearance rate was 32% higher (0.33 +/- 0.03 vs. 0.25 +/- 0.02 microgram/m2/min, p less than .016) and NE clearance was 19% lower (1.21 +/- 0.08 vs. 1.49 +/- 0.06 L/min/m2, p less than .006) in the older participants. There was a close correlation between NE appearance rate and NE levels (r = .76, p less than .001, N = 43), but only modest inverse correlation between NE clearance and NE levels (r = -.37, p less than .01, N = 43). Stepwise multiple linear regression analysis revealed that NE appearance rate and clearance explained 80% of the variance in NE levels and that 57% of the variance was attributable to NE appearance, F (1,41)more »
- Authors:
- Publication Date:
- Research Org.:
- Education and Clinical Center, Seattle, WA
- OSTI Identifier:
- 5654294
- Resource Type:
- Journal Article
- Journal Name:
- J. Gerontol.; (United States)
- Additional Journal Information:
- Journal Volume: 3
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; NORADRENALINE; BIOCHEMICAL REACTION KINETICS; AGE DEPENDENCE; AGING; BLOOD PLASMA; BLOOD PRESSURE; BLOOD-PLASMA CLEARANCE; ISOTOPE DILUTION; REGRESSION ANALYSIS; TRITIUM COMPOUNDS; ADRENAL HORMONES; AUTONOMIC NERVOUS SYSTEM AGENTS; BIOLOGICAL MATERIALS; BLOOD; BODY FLUIDS; CARDIOTONICS; CARDIOVASCULAR AGENTS; CLEARANCE; DRUGS; HORMONES; ISOTOPE APPLICATIONS; KINETICS; LABELLED COMPOUNDS; MATERIALS; MATHEMATICS; NEUROREGULATORS; REACTION KINETICS; STATISTICS; STEROID HORMONES; SYMPATHOMIMETICS; TRACER TECHNIQUES; 550201* - Biochemistry- Tracer Techniques
Citation Formats
Veith, R C, Featherstone, J A, Linares, O A, and Halter, J B. Age differences in plasma norepinephrine kinetics in humans. United States: N. p., 1986.
Web. doi:10.1093/geronj/41.3.319.
Veith, R C, Featherstone, J A, Linares, O A, & Halter, J B. Age differences in plasma norepinephrine kinetics in humans. United States. https://doi.org/10.1093/geronj/41.3.319
Veith, R C, Featherstone, J A, Linares, O A, and Halter, J B. 1986.
"Age differences in plasma norepinephrine kinetics in humans". United States. https://doi.org/10.1093/geronj/41.3.319.
@article{osti_5654294,
title = {Age differences in plasma norepinephrine kinetics in humans},
author = {Veith, R C and Featherstone, J A and Linares, O A and Halter, J B},
abstractNote = {To determine if the increased plasma norepinephrine (NE) of older individuals is due to greater plasma NE appearance rate and/or decreased NE clearance, arterialized plasma NE kinetics were measured in 25 healthy young (27 +/- 6 yr, M +/- SD) and 18 healthy older volunteers (68 +/- 5 yr) using a tritium-labeled NE isotope dilution technique. Basal NE levels were 54% greater in the older participants (282 +/- 24 vs. 183 +/- 11 pg/ml, M +/- SEM, p less than .001). The mean plasma NE appearance rate was 32% higher (0.33 +/- 0.03 vs. 0.25 +/- 0.02 microgram/m2/min, p less than .016) and NE clearance was 19% lower (1.21 +/- 0.08 vs. 1.49 +/- 0.06 L/min/m2, p less than .006) in the older participants. There was a close correlation between NE appearance rate and NE levels (r = .76, p less than .001, N = 43), but only modest inverse correlation between NE clearance and NE levels (r = -.37, p less than .01, N = 43). Stepwise multiple linear regression analysis revealed that NE appearance rate and clearance explained 80% of the variance in NE levels and that 57% of the variance was attributable to NE appearance, F (1,41) = 54.8, p less than .001, compared with only 14% by NE clearance, F (1, 41) = 6.5, p = .01. We conclude that the principal factor accounting for the higher plasma NE levels of older individuals is an increase in plasma NE appearance rate.},
doi = {10.1093/geronj/41.3.319},
url = {https://www.osti.gov/biblio/5654294},
journal = {J. Gerontol.; (United States)},
number = ,
volume = 3,
place = {United States},
year = {Thu May 01 00:00:00 EDT 1986},
month = {Thu May 01 00:00:00 EDT 1986}
}