Effect of age on left ventricular function during exercise in patients with coronary artery disease

Journal Article · Sat Oct 01 00:00:00 EDT 1983 · J. Am. Coll. Cardiol.; (United States)

DOI:https://doi.org/10.1016/S0735-1097(83)80304-0· OSTI ID:5653835

Hakki, A H; DePace, N L; Iskandrian, A S

The purpose of this study was to assess the effect of age on left ventricular performance during exercise in 79 patients with coronary artery disease (greater than or equal to 50% narrowing of one or more major coronary arteries). Fifty patients under the age of 60 years (group I) and 29 patients 60 years or older (group II) were studied. Radionuclide angiograms were obtained at rest and during symptom-limited upright bicycle exercise. The history of hypertension, angina or Q wave myocardial infarction was similar in both groups. Multivessel coronary artery disease was present in 30 patients (60%) in group I and in 19 patients (66%) in group II (p . not significant). There were no significant differences between the two groups in the hemodynamic variables (at rest or during exercise) of left ventricular ejection fraction, end-diastolic volume, end-systolic volume and cardiac index. Exercise tolerance was higher in group I than in group II (7.8 +/- 0.4 versus 5.7 +/- 0.4 minutes, p . 0.009), although the exercise heart rate and rate-pressure product were not significantly different between the groups. There was poor correlation between age and ejection fraction, end-diastolic volume and end-systolic volume at rest and during exercise. Abnormal left ventricular function at rest or an abnormal response to exercise was noted in 42 patients (84%) in group I and in 25 patients (86%) in group II (p . not significant). Thus, in patients with coronary artery disease, age does not influence left ventricular function at rest or response to exercise. Older patients with coronary artery disease show changes in left ventricular function similar to those in younger patients with corresponding severity of coronary artery disease.

• Research Organization: Likoff Cardiovascular Institute of Hahnemann University and Hospital, Philadelphia, Pennsylvania
• OSTI ID: 5653835
• Journal Information: J. Am. Coll. Cardiol.; (United States), Vol. 2:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
HEART
BLOOD CIRCULATION
CARDIOGRAPHY
AGE DEPENDENCE
CARDIOVASCULAR DISEASES
CORONARIES
DYNAMIC FUNCTION STUDIES
ELDERLY PEOPLE
EXERCISE
FEMALES
HYPERTENSION
MALES
PATIENTS
TECHNETIUM ISOTOPES
AGE GROUPS
ARTERIES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
DIAGNOSTIC TECHNIQUES
DISEASES
HUMAN POPULATIONS
ISOTOPES
MINORITY GROUPS
ORGANS
POPULATIONS
SYMPTOMS
VASCULAR DISEASES
550601* - Medicine- Unsealed Radionuclides in Diagnostics