Roles of mucosal mast cells in intestinal cell-mediated immunity

Journal Article · Sun Nov 01 00:00:00 EST 1987 · Ann. Allergy; (United States)

OSTI ID:5650071

Ferguson, A; Cummins, A G; Munro, G H; Gibson, S; Miller, H R

Mucosal mast cells in rats with GvHR have been studied by cell counts, tissue levels of the specific protease RMCPII, and, as an index of MMC activation, serum RMCPII. In semi-allogeneic GvHR without host irradiation, GvHR produced modest increases in these three indices. In contrast, irradiation profoundly depleted MMC even though enteropathy was more severe than in non-irradiated hosts. We suggest that enteropathy is not dependent on the presence of MMC. In rats given cyclosporin A, lesions of GvHR were mild and numbers of MMC were low.

• Research Organization: Univ. of Edinburgh, Scotland, England
• OSTI ID: 5650071
• Journal Information: Ann. Allergy; (United States), Vol. 59
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MAST CELLS
BIOLOGICAL FUNCTIONS
RATS
GRAFT-HOST REACTION
BIOLOGICAL RADIATION EFFECTS
IMMUNITY
IMMUNOSUPPRESSIVE DRUGS
INTESTINES
IRRADIATION
MUCOUS MEMBRANES
SERINE PROTEINASES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DRUGS
ENZYMES
FUNCTIONS
GASTROINTESTINAL TRACT
HYDROLASES
MAMMALS
MEMBRANES
ORGANS
PEPTIDE HYDROLASES
RADIATION EFFECTS
RODENTS
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals