Metabolism and excretion of orally administered arsenobetaine in the hamster

Journal Article · Sat Mar 01 00:00:00 EST 1986 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01623519· OSTI ID:5649681

Yamauchi, H; Kaise, T; Yamamura, Y

Arsenobetaine, one of the trimethylarsenic compounds (TMA), occurs abundantly in seafoods. The urinary excretion pattern of arsenic in man following oral ingestion of TMA contained in fishes once only indicates that the most portion of the TMA is excreted in urine. These experiments in humans have used fish arsenic but no authentic arsenobetaine. From previous experiments in mice, rats and rabbits using/sup 73/As-labeled arsenobetaine, it was reported that arsenobetaine is not converted in vivo into any other chemical species of arsenic. The metabolic and excretory patterns of arsenic compounds in the hamster seem to be similar to those in humans. In the present study, the authors examined arsenobetaine-treated hamsters for what chemical species of arsenic this arsenic compound (arsenobetaine) would be metabolized into in vivo and also for its excretory patterns in urine and feces with time.

• Research Organization: St. Marianna Univ. School of Medicine, Kawasaki, Japan
• OSTI ID: 5649681
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Vol. 36:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ORGANIC ARSENIC COMPOUNDS
EXCRETION
METABOLISM
FECES
HAMSTERS
ORAL ADMINISTRATION
URINE
ANIMALS
ARSENIC COMPOUNDS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CLEARANCE
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
RODENTS
VERTEBRATES
WASTES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)