Effects of ozone and sulfuric acid aerosol on gas trapping in the guinea pig lung
Four groups of 20 guinea pigs were sequentially exposed by inhalation to either air followed by sulfuric acid aerosol, ozone followed by sulfuric acid aerosol, ozone followed by air, or air followed by air to determine whether ozone preexposure sensitizes guinea pigs to the airway constrictive effects of sulfuric acid aerosol. All first exposures to ozone or air were 2 h in duration; all second exposures to sulfuric acid or air were for 1 h. All ozone and sulfuric acid exposures were 0.8 ppm and 12 mg/m3, respectively. Animals were observed for respiratory distress during exposure, and excised lungs were quantitated for trapped gas and wet/dry ratios. None of the guinea pigs developed dyspnea, and wet/dry ratios were not altered. Ozone significantly (p less than 0.05) increased trapped gas volumes, which were 44% (ozone-acid) to 68% (ozone-air) greater than in the air-air group. Trapped gas volume was 23% greater in the ozone-acid group than in the air-acid group, but the difference was not statistically significant (p less than 0.20). Thus, ozone increased gas trapping but did not significantly sensitize guinea pigs to the bronchoconstrictive action of sulfuric acid.
- Research Organization:
- Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM
- OSTI ID:
- 5649624
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
OZONE
BIOLOGICAL EFFECTS
SULFURIC ACID
AEROSOLS
GUINEA PIGS
INHALATION
KINETICS
LUNGS
SYNERGISM
ANIMALS
BODY
COLLOIDS
DISPERSIONS
HYDROGEN COMPOUNDS
INORGANIC ACIDS
INTAKE
MAMMALS
ORGANS
RESPIRATORY SYSTEM
RODENTS
SOLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)