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Title: Indium-111 chloride imaging in the detection of infected prostheses

Thirty-three patients with painful joint prostheses and a suspicion of infection were imaged with (/sup 111/In)chloride. A final diagnosis was established by culture in 19. Of these, 12 were categorized as true positives and three as true negatives. There were two false-positive studies, occurring in patients with knee prostheses. In both, the culture was obtained by aspiration. The sensitivity was 86%, specificity 60%, and accuracy 79%. Seventeen of the proven cases had bone imaging prior to (/sup 111/In)chloride imaging. All 17 static images were positive and were not helpful in differentiating loosening from infection. Using increased uptake on the blood-pool image as a criteria for infection, the sensitivity was 89%, but the specificity was 0. Adding flow studies made little difference in interpreting the blood-pool images. This study shows that (/sup 111/In)chloride imaging is more accurate in evaluating infection in prosthesis than bone imaging.
Authors:
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Publication Date:
OSTI Identifier:
5645932
Resource Type:
Journal Article
Resource Relation:
Journal Name: J. Nucl. Med.; (United States); Journal Volume: 26:7
Research Org:
Univ. of Texas Medical Branch, Galveston
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD FLOW; SCINTISCANNING; INFECTIOUS DISEASES; DIAGNOSIS; BONE JOINTS; INDIUM 111; INDIUM CHLORIDES; PATIENTS; PROSTHESES; BETA DECAY RADIOISOTOPES; BODY; CHLORIDES; CHLORINE COMPOUNDS; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; HALIDES; HALOGEN COMPOUNDS; INDIUM COMPOUNDS; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEDICAL SUPPLIES; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SKELETON 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics