Iodine-125 implant and external beam irradiation in patients with localized pancreatic carcinoma. [Efficacy and complications]
Twelve patients with biopsy-proven clinically localized ductal pancreatic cancers (less than 7 cm in greatest diameter) judged unsuitable for resection were treated by bypass surgery, an Iodine-125 implant (20 to 39 mCi), and postoperative irradiation (4000 to 4500 rads). The potential problems of significant bleeding, pancreatic fistula, or pancreatitis were not experienced. A local recurrence developed in one patient and two recurred in regional lymph nodes. The projected median survival of the group is 11 months with four of the 12 patients still surviving. For purposes of comparison all patients with pancreatic ductal carcinoma treated by radical resection during a similar time were evaluated. All ten have died with a median survival of six months. Twelve of 22 (55%) of the combined implanted and resected groups have developed distant metastasis. Further pursuit of intraoperative techniques of irradiation in combination with adjuvant multidrug chemotherapy seems indicated in an attempt to prolong patient survival which is now limited by hematogenous metastases.
- Research Organization:
- Massachusetts General Hospital, Boston
- OSTI ID:
- 5643971
- Journal Information:
- Cancer; (United States), Vol. 45:4; Conference: 20. annual meeting of the American Society of Therapeutic Radiologists, Los Angeles, CA, USA, 1 Nov 1978
- Country of Publication:
- United States
- Language:
- English
Similar Records
Treatment of primary unresectable carcinoma of the pancreas with I-125 implantation
Intraoperative electron beam irradiation for patients with unresectable pancreatic carcinoma
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
DIGESTIVE SYSTEM DISEASES
RADIOINDUCTION
HEMORRHAGE
INFLAMMATION
PANCREAS
DELAYED RADIATION EFFECTS
RADIOTHERAPY
SIDE EFFECTS
STOMACH
EARLY RADIATION EFFECTS
ULCERS
CARCINOMAS
COMPARATIVE EVALUATIONS
DATA COMPILATION
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
INTERNAL IRRADIATION
IODINE 125
ISOLATED VALUES
LOCAL IRRADIATION
PATIENTS
RADIATION SOURCE IMPLANTS
SURGERY
X RADIATION
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GASTROINTESTINAL TRACT
GLANDS
IMPLANTS
INFORMATION
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATION SOURCES
RADIATIONS
RADIOISOTOPES
RADIOLOGY
SYMPTOMS
THERAPY
560151* - Radiation Effects on Animals- Man
560161 - Radionuclide Effects
Kinetics
& Toxicology- Man
550603 - Medicine- External Radiation in Therapy- (1980-)
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)