Tellurium-123m-labeled 23-(isopropyl telluro)-24-nor-5. cap alpha. -cholan-3. beta. -ol: a new potential adrenal imaging agent
Tellurium-123m-labeled 23-(isopropyl telluro)-24-nor-5..cap alpha..-cholan-3..beta..-ol (24-telluracholestanol, or 23-ITC) has been prepared as a potential adrenal-imaging agent. The new agent was synthesized by the coupling of 3..beta..-acetoxy-23-bromo-24-nor-5..cap alpha..-cholan with Te-123m-labeled sodium isopropyl tellurol. Tissue distribution experiments in both male and female rats indicate a high adrenal concentration of radioactivity following administration of this agent. In female rats the adrenal glands accumulated 4.5% of the injected radioactivity only 1 day after administration of Te-123m-23-ITC. The adrenal-to-liver ratio was 42 after 1 day, and this increased to 100 after 3 days. Chromatographic analyses of lipid extracts from adrenal, ovary, liver, and lungs suggest that this agent is metabolized by these tissues. Examination of the rats' excretory products has indicated that approximately 50% of the administered radioactivity is excreted in the feces with 5 days after injection of Te-123m-23-ITC. Moreover, the adrenals and ovaries of rats have been clearly imaged with this agent, both with a rectilinear scanner and with an RC type of proportional-counter camera.
- Research Organization:
- Oak Ridge National Lab., TN
- OSTI ID:
- 5643403
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 23:3
- Country of Publication:
- United States
- Language:
- English
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38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL GLANDS
BIOLOGICAL LOCALIZATION
RADIONUCLIDE KINETICS
OVARIES
RADIOPHARMACEUTICALS
BIOLOGICAL ACCUMULATION
CHEMICAL PREPARATION
TISSUE DISTRIBUTION
STEROIDS
LABELLING
TELLURIUM 123
RADIOCHEMISTRY
EXPERIMENTAL DATA
INTRAVENOUS INJECTION
ISOLATED VALUES
ISOMERIC NUCLEI
RATS
ANIMALS
BODY
CHEMISTRY
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DRUGS
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
FEMALE GENITALS
GLANDS
GONADS
INFORMATION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
NUCLEI
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
RADIOACTIVE MATERIALS
RADIOISOTOPES
RODENTS
STABLE ISOTOPES
SYNTHESIS
TELLURIUM ISOTOPES
VERTEBRATES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
550601 - Medicine- Unsealed Radionuclides in Diagnostics