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Title: Hepatic folate metabolism in the chronic alcoholic monkey

Abstract

To assess the role of altered hepatic folate metabolism in the pathogenesis of the folate deficiency of chronic alcoholism, the hepatic metabolism of a tracer dose of /sup 3/H-PteGlu was compared in monkeys given 50% of energy as ethanol for 2 years and in control monkeys. Long-term ethanol feeding resulted in mild hepatic injury, with a significant decrease in hepatic folate levels. Chromatographic studies of liver biopsies obtained after the tracer dose indicated that the processes of reduction, methylation, and formylation of reduced folate and the synthesis of polyglutamyl folates were not affected by long-term ethanol feeding. Hepatic tritium levels were significantly decreased in the ethanol-fed group. These studies suggest that the decrease in hepatic folate levels observed after long-term ethanol ingestion is due to a decrease in hepatic folate levels observed after long-term ethanol ingestion is due to a decreased ability to retain folates in the liver, whereas reduction and further metabolism of folates is not affected.

Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
5639483
Resource Type:
Journal Article
Journal Name:
J. Lab. Clin. Med.; (United States)
Additional Journal Information:
Journal Volume: 97:5
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ETHANOL; BIOLOGICAL EFFECTS; FOLIC ACID; METABOLISM; TRITIUM COMPOUNDS; TRACER TECHNIQUES; DIET; LIVER; MONKEYS; ALCOHOLS; AMINO ACIDS; ANIMALS; BODY; CARBOXYLIC ACIDS; DIGESTIVE SYSTEM; DRUGS; GLANDS; HEMATINICS; HEMATOLOGIC AGENTS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PRIMATES; PTERIDINES; VERTEBRATES; VITAMIN B GROUP; VITAMINS; 550301* - Cytology- Tracer Techniques; 551001 - Physiological Systems- Tracer Techniques

Citation Formats

Tamura, T, Romero, J J, Watson, J E, Gong, E J, and Halsted, C H. Hepatic folate metabolism in the chronic alcoholic monkey. United States: N. p., 1981. Web.
Tamura, T, Romero, J J, Watson, J E, Gong, E J, & Halsted, C H. Hepatic folate metabolism in the chronic alcoholic monkey. United States.
Tamura, T, Romero, J J, Watson, J E, Gong, E J, and Halsted, C H. 1981. "Hepatic folate metabolism in the chronic alcoholic monkey". United States.
@article{osti_5639483,
title = {Hepatic folate metabolism in the chronic alcoholic monkey},
author = {Tamura, T and Romero, J J and Watson, J E and Gong, E J and Halsted, C H},
abstractNote = {To assess the role of altered hepatic folate metabolism in the pathogenesis of the folate deficiency of chronic alcoholism, the hepatic metabolism of a tracer dose of /sup 3/H-PteGlu was compared in monkeys given 50% of energy as ethanol for 2 years and in control monkeys. Long-term ethanol feeding resulted in mild hepatic injury, with a significant decrease in hepatic folate levels. Chromatographic studies of liver biopsies obtained after the tracer dose indicated that the processes of reduction, methylation, and formylation of reduced folate and the synthesis of polyglutamyl folates were not affected by long-term ethanol feeding. Hepatic tritium levels were significantly decreased in the ethanol-fed group. These studies suggest that the decrease in hepatic folate levels observed after long-term ethanol ingestion is due to a decrease in hepatic folate levels observed after long-term ethanol ingestion is due to a decreased ability to retain folates in the liver, whereas reduction and further metabolism of folates is not affected.},
doi = {},
url = {https://www.osti.gov/biblio/5639483}, journal = {J. Lab. Clin. Med.; (United States)},
number = ,
volume = 97:5,
place = {United States},
year = {Fri May 01 00:00:00 EDT 1981},
month = {Fri May 01 00:00:00 EDT 1981}
}