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Title: Sequential serum thyroglobulin determinations, /sup 131/I scans, and /sup 131/I uptakes after triiodothyronine withdrawal in patients with thyroid cancer

Abstract

To develop guidelines for the timing and interpretation of thyroglobulin (TG) measurements in patients with well differentiated thyroid cancer, we performed /sup 131/I whole body scans and uptakes with simultaneous serum TG and TSH determinations in 49 patients with this disease. In 15 patients, TG measurements were obtained initially while the patient was receiving T/sub 3/ therapy and then were repeated serially within a period of up to 35 days after T/sub 3/ withdrawal. In 9 patients with functioning thyroid tissue, the changes in TG paralleled the changes in TSH levels. Before stopping T/sub 3/, TG measurements were a poor indicator of function, since 14 of 15 patients had suppressed TG levels (<10 ng/ml). After 2 weeks off T/sub 3/, TG increased in all 5 patients with scan evidence of metastases, in 2 of 4 subjects with residual thyroid bed uptake, and in 2 of 6 patients with no uptake. In 23 patients, both the scan and serum TG measurements were performed 2 and 4 weeks after stopping T/sub 3/. At 4 weeks, compared to 2 weeks, TG levels were nearly the same in 17 (a change of <5 ng/ml and <50%), decreased in 1, and increased in 5 subjects.more » In 44 patients whose measurements were free of interference from anti-TG, 106 scans and serum TG determinations were performed after stopping thyroid hormone replacement. Scan evidence of metastases was always (22 scans) associated with high serum TG levels (>10 ng/ml), but high serum TG levels did not distinguish metastases from residual thyroid tissue. The serum TG level was greater than 10 ng/ml in 5 of 28 instances (18%) of negative scans, while scans were positive in 14 of 32 instances (44%) where TG levels were less than 2 ng/ml.« less

Authors:
; ; ;
Publication Date:
OSTI Identifier:
5639312
Resource Type:
Journal Article
Journal Name:
J. Clin. Endocrinol. Metab.; (United States)
Additional Journal Information:
Journal Volume: 53:6
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; IODINE 131; WHOLE-BODY COUNTING; THYROGLOBULIN; RADIOIMMUNOASSAY; THYROID; BIOLOGICAL FUNCTIONS; CHEMOTHERAPY; DIAGNOSIS; NEOPLASMS; RADIOPHARMACEUTICALS; TIME DEPENDENCE; TRIIODOTHYRONINE; TSH; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; ENDOCRINE GLANDS; FUNCTIONS; GLANDS; GLOBULINS; HORMONES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PITUITARY HORMONES; PROTEINS; RADIOASSAY; RADIOISOTOPES; THERAPY; THYROID HORMONES; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Schneider, A B, Coney Island Hospital, Brooklyn, NY), Line, B R, Goldman, J M, and Robbins, J. Sequential serum thyroglobulin determinations, /sup 131/I scans, and /sup 131/I uptakes after triiodothyronine withdrawal in patients with thyroid cancer. United States: N. p., 1981. Web. doi:10.1210/jcem-53-6-1199.
Schneider, A B, Coney Island Hospital, Brooklyn, NY), Line, B R, Goldman, J M, & Robbins, J. Sequential serum thyroglobulin determinations, /sup 131/I scans, and /sup 131/I uptakes after triiodothyronine withdrawal in patients with thyroid cancer. United States. https://doi.org/10.1210/jcem-53-6-1199
Schneider, A B, Coney Island Hospital, Brooklyn, NY), Line, B R, Goldman, J M, and Robbins, J. 1981. "Sequential serum thyroglobulin determinations, /sup 131/I scans, and /sup 131/I uptakes after triiodothyronine withdrawal in patients with thyroid cancer". United States. https://doi.org/10.1210/jcem-53-6-1199.
@article{osti_5639312,
title = {Sequential serum thyroglobulin determinations, /sup 131/I scans, and /sup 131/I uptakes after triiodothyronine withdrawal in patients with thyroid cancer},
author = {Schneider, A B and Coney Island Hospital, Brooklyn, NY) and Line, B R and Goldman, J M and Robbins, J},
abstractNote = {To develop guidelines for the timing and interpretation of thyroglobulin (TG) measurements in patients with well differentiated thyroid cancer, we performed /sup 131/I whole body scans and uptakes with simultaneous serum TG and TSH determinations in 49 patients with this disease. In 15 patients, TG measurements were obtained initially while the patient was receiving T/sub 3/ therapy and then were repeated serially within a period of up to 35 days after T/sub 3/ withdrawal. In 9 patients with functioning thyroid tissue, the changes in TG paralleled the changes in TSH levels. Before stopping T/sub 3/, TG measurements were a poor indicator of function, since 14 of 15 patients had suppressed TG levels (<10 ng/ml). After 2 weeks off T/sub 3/, TG increased in all 5 patients with scan evidence of metastases, in 2 of 4 subjects with residual thyroid bed uptake, and in 2 of 6 patients with no uptake. In 23 patients, both the scan and serum TG measurements were performed 2 and 4 weeks after stopping T/sub 3/. At 4 weeks, compared to 2 weeks, TG levels were nearly the same in 17 (a change of <5 ng/ml and <50%), decreased in 1, and increased in 5 subjects. In 44 patients whose measurements were free of interference from anti-TG, 106 scans and serum TG determinations were performed after stopping thyroid hormone replacement. Scan evidence of metastases was always (22 scans) associated with high serum TG levels (>10 ng/ml), but high serum TG levels did not distinguish metastases from residual thyroid tissue. The serum TG level was greater than 10 ng/ml in 5 of 28 instances (18%) of negative scans, while scans were positive in 14 of 32 instances (44%) where TG levels were less than 2 ng/ml.},
doi = {10.1210/jcem-53-6-1199},
url = {https://www.osti.gov/biblio/5639312}, journal = {J. Clin. Endocrinol. Metab.; (United States)},
number = ,
volume = 53:6,
place = {United States},
year = {Tue Dec 01 00:00:00 EST 1981},
month = {Tue Dec 01 00:00:00 EST 1981}
}