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Title: Hepatic contrast agents for computed tomography: high atomic number particulate material

We used a stepwise approach to identify, design, synthesize, and test new high atomic number particulate contrast agents that would be especially well suited for use with computed tomography (CT). Our goal was to produce extremely radiopaque compounds with highly selective biodistribution to the normal liver. In this way, dose requirements could be lessened and toxicity minimized. Suspensions of cerium, gadolinium, and dysprosium oxide particles and silver iodide colloid were tested and compared with standard agents. All four experimental agents were selectively concentrated in the reticuloendothelial systems of rats and rabbits. These compounds produced greater and longer opacification of normal livers and larger liver-to-tumor differences in rabbits with hepatic tumors than did equivalent amounts of standard, iodinated agents. Lesions as small as 5 mm were visible with CT. These experimental materials have favorable characteristics as hepatic contrast agents, but their toxicity and long term retention may limit clinical use.
Authors:
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Publication Date:
OSTI Identifier:
5638896
Resource Type:
Journal Article
Resource Relation:
Journal Name: J. Comput. Assist. Tomogr.; (United States); Journal Volume: 5:3
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CERIUM; DIAGNOSTIC USES; DYSPROSIUM OXIDES; GADOLINIUM; LIVER; COMPUTERIZED TOMOGRAPHY; SILVER IODIDES; BIOLOGICAL LOCALIZATION; CHEMICAL PREPARATION; CONTRAST MEDIA; DESIGN; RABBITS; RADIATION DOSES; RATS; RETICULOENDOTHELIAL SYSTEM; TISSUE DISTRIBUTION; TOXICITY; ANIMAL TISSUES; ANIMALS; BODY; CHALCOGENIDES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISTRIBUTION; DOSES; DYSPROSIUM COMPOUNDS; ELEMENTS; GLANDS; HALIDES; HALOGEN COMPOUNDS; IODIDES; IODINE COMPOUNDS; MAMMALS; METALS; ORGANS; OXIDES; OXYGEN COMPOUNDS; RARE EARTH COMPOUNDS; RARE EARTHS; RODENTS; SILVER COMPOUNDS; SYNTHESIS; TISSUES; TOMOGRAPHY; TRANSITION ELEMENT COMPOUNDS; USES; VERTEBRATES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics; 550901 -- Pathology-- Tracer Techniques; 560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)