Hepatic contrast agents for computed tomography: high atomic number particulate material

Journal Article · Mon Jun 01 00:00:00 EDT 1981 · J. Comput. Assist. Tomogr.; (United States)

DOI:https://doi.org/10.1097/00004728-198106000-00011· OSTI ID:5638896

Seltzer, S E; Adams, D F; Davis, M A; Hessel, S J; Havron, A; Judy, P F; Paskins-Hurlburt, A J; Hollenberg, N K

We used a stepwise approach to identify, design, synthesize, and test new high atomic number particulate contrast agents that would be especially well suited for use with computed tomography (CT). Our goal was to produce extremely radiopaque compounds with highly selective biodistribution to the normal liver. In this way, dose requirements could be lessened and toxicity minimized. Suspensions of cerium, gadolinium, and dysprosium oxide particles and silver iodide colloid were tested and compared with standard agents. All four experimental agents were selectively concentrated in the reticuloendothelial systems of rats and rabbits. These compounds produced greater and longer opacification of normal livers and larger liver-to-tumor differences in rabbits with hepatic tumors than did equivalent amounts of standard, iodinated agents. Lesions as small as 5 mm were visible with CT. These experimental materials have favorable characteristics as hepatic contrast agents, but their toxicity and long term retention may limit clinical use.

• OSTI ID: 5638896
• Journal Information: J. Comput. Assist. Tomogr.; (United States), Vol. 5:3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CERIUM
DIAGNOSTIC USES
DYSPROSIUM OXIDES
GADOLINIUM
LIVER
COMPUTERIZED TOMOGRAPHY
SILVER IODIDES
BIOLOGICAL LOCALIZATION
CHEMICAL PREPARATION
CONTRAST MEDIA
DESIGN
RABBITS
RADIATION DOSES
RATS
RETICULOENDOTHELIAL SYSTEM
TISSUE DISTRIBUTION
TOXICITY
ANIMAL TISSUES
ANIMALS
BODY
CHALCOGENIDES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DOSES
DYSPROSIUM COMPOUNDS
ELEMENTS
GLANDS
HALIDES
HALOGEN COMPOUNDS
IODIDES
IODINE COMPOUNDS
MAMMALS
METALS
ORGANS
OXIDES
OXYGEN COMPOUNDS
RARE EARTH COMPOUNDS
RARE EARTHS
RODENTS
SILVER COMPOUNDS
SYNTHESIS
TISSUES
TOMOGRAPHY
TRANSITION ELEMENT COMPOUNDS
USES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550901 - Pathology- Tracer Techniques
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)