Effect of various doses of chalone-containing alcohol precipitate from Ehrlich's ascites tumor on mitotic activity and DNA synthesis in that tumor

Journal Article · Mon Jun 01 00:00:00 EDT 1987 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

DOI:https://doi.org/10.1007/BF00840153· OSTI ID:5625349

Matsak, N Ya; Romanov, Yu A; Antokhin, A I

Experiments were carried out on noninbred male albino mice to assess the effects of varying doses of chalone-containing alcohol precipitates on mitotic activity and DNA synthesis in Ehrlich ascites tumor. Histological preparations of the tumor and small intestine were made by standard methods. Hydrolysis of the tumor in HCl was carried out before application of the nuclear photographic emulsion in order to prepare autoradiographs of the tumor. Tritium-labelled thymidine was injected as the radioactive marker.

• Research Organization: N. I. Pirogov Second Moscow Medical Institute, USSR
• OSTI ID: 5625349
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 103:1; Other Information: Translated from Byulleten' Ehksperimental'noj Biologii i Meditsiny; 103: No. 1, 89-92(Jan 1987)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
BIOLOGICAL EFFECTS
DOSE-RESPONSE RELATIONSHIPS
DNA
BIOSYNTHESIS
MICE
EHRLICH ASCITES TUMOR
POLYPEPTIDES
TUMOR CELLS
AUTORADIOGRAPHY
CELL PROLIFERATION
CYTOCHEMISTRY
DNA REPLICATION
TRACER TECHNIQUES
EPITHELIUM
INHIBITION
MITOTIC INDEX
SMALL INTESTINE
THYMIDINE
TRITIUM COMPOUNDS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AZINES
BIOCHEMISTRY
BODY
CHEMISTRY
DIGESTIVE SYSTEM
EXPERIMENTAL NEOPLASMS
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INTESTINES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDES
PROTEINS
PYRIMIDINES
RIBOSIDES
RODENTS
SYNTHESIS
TISSUES
VERTEBRATES
550901* - Pathology- Tracer Techniques
550301 - Cytology- Tracer Techniques