Effect of 2450-MHz microwave energy on the blood-brain barrier to hydrophilic molecules

Thesis/Dissertation · Sat Jan 01 00:00:00 EST 1983

OSTI ID:5616524

Williams, W M

Microwave energy at 2450 MHz 120 Hz AM was found ineffective in increasing the permeability of the blood-brain barrier to the hydrophilic tracers HRP and (/sup 14/C) sucrose. Furthermore, a diminished permeability to HRP and sodium fluorescein was apparent after 180 minutes of exposure to microwaves at an incident power density of 20 mW/cm/sup 2/. Colonic temperature, as well as temperature within the cerebral cortex, hypothalamus, cerebellum and medulla, were elevated by less than 1/sup 0/C over those of sham-exposed rats. A significant decrease in the permeability to HRP and (/sup 14/C) sucrose occurred after exposure to an incident power density of 65 mW/cm/sup 2/ for 30 minutes. The reduction in permeability to HRP correlated with a suppressed incorporation of the tracer by pinocytosis in cerebral microvessels. Suppression of blood-brain barrier permeability to hydrophilic tracers was most pronounced at brain temperatures exceeding approx. 40/sup 0/C and is demonstrated to be temperature dependent.

• Research Organization: Rochester Univ., NY (USA)
• OSTI ID: 5616524
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BLOOD-BRAIN BARRIER
PERMEABILITY
MICROWAVE RADIATION
BIOLOGICAL EFFECTS
BODY TEMPERATURE
CARBON 14 COMPOUNDS
HYPERTHERMIA
MHZ RANGE
RATS
ANIMALS
ELECTROMAGNETIC RADIATION
FREQUENCY RANGE
LABELLED COMPOUNDS
MAMMALS
RADIATIONS
RODENTS
VERTEBRATES
560400* - Other Environmental Pollutant Effects
560205 - Thermal Effects- Vertebrates- (-1987)