skip to main content

Title: Hepatic injury after whole-liver irradiation in the rat

Radiation-induced hepatic injury in rats, which is characterized by marked ascites accompanied by liver necrosis, fibrosis, and vein lesions, is described in this study. These adverse sequelae are produced within 30 days after irradiation if there is surgical removal of two-thirds of the liver immediately after whole-liver irradiation. The LD/sub 50/30/ day and median survival time after liver irradiation and two-thirds partial hepatectomy is 24 Gy and 17 days, respectively. Death is preceded by reduction in liver function as measured by (/sup 131/I)-labeled rose bengal clearance. Prior to death, liver sepsis and endotoxemia were detected in most irradiated, partially hepatectomized animals. Pretreatment of the animals with endotoxin and/or antibiotic decontamination of the GI tract resulted in increased survival time, but no irradiated, partially hepatectomized animal survived beyond 63 days. This suggests that sepsis and endotoxemia resulting from the bacteria in the intestine are the immediate cause of death after 30-Gy liver irradiation and partial hepatectomy. It is concluded that the hepatectomized rat model is an economical and scientifically manageable experimental system to study a form of radiation hepatitis that occurs in compromised human livers.
Authors:
; ; ;
Publication Date:
OSTI Identifier:
5612068
Resource Type:
Journal Article
Resource Relation:
Journal Name: Radiat. Res.; (United States); Journal Volume: 101:3
Research Org:
Univ. of Washington, Seattle
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ASCITES; RADIOINDUCTION; FIBROSIS; LIVER; BIOLOGICAL RADIATION EFFECTS; PARTIAL BODY IRRADIATION; NECROSIS; CESIUM 137; GAMMA RADIATION; HEPATECTOMY; IODINE 131; RATS; ALKALI METAL ISOTOPES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BODY; CESIUM ISOTOPES; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; GLANDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; IONIZING RADIATIONS; IRRADIATION; ISOTOPES; MAMMALS; MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RODENTS; SURGERY; SYMPTOMS; VERTEBRATES; YEARS LIVING RADIOISOTOPES 560152* -- Radiation Effects on Animals-- Animals