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Title: Dosimetry of Auger emitters: Physical and phenomenological approaches

Recent radiobiological studies have demonstrated that Auger cascades can cause severe biological damage contrary to expectations based on conventional dosimetry. Several determinants govern these effects, including the nature of the Auger electron spectrum; localized energy deposition; cellular geometry; chemical form of the carrier; cellular localization, concentration, and subcellular distribution of the radionuclide. Conventional dosimetry is inadequate in that these considerations are ignored. Our results provide the basis for biophysical approaches toward subcellular dosimetry of Auger emitters in vitro and in vivo. 12 refs., 7 figs., 2 tabs.
Authors:
; ; ; ; ; ; ; ;
Publication Date:
OSTI Identifier:
5606399
Report Number(s):
CONF-8707137-1
ON: DE88002786
DOE Contract Number:
AC05-84OR21400
Resource Type:
Conference
Resource Relation:
Conference: Workshop on aspects of dosimetry of internally incorporation Auger emitters, Harwell, UK, 17 Jul 1987; Other Information: Paper copy only, copy does not permit microfiche production
Research Org:
Massachusetts Univ., Amherst (USA). Dept. of Physics and Astronomy; University of Medicine and Dentistry of New Jersey, Newark (USA). Dept. of Radiology; Harvard Univ., Boston, MA (USA). Shields Warren Radiation Lab.; Oak Ridge National Lab., TN (USA)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; AUGER EFFECT; BIOLOGICAL RADIATION EFFECTS; INTERNAL IRRADIATION; MATHEMATICAL MODELS; LET; BIOLOGICAL EFFECTS; AUTOIONIZATION; BROMINE 77; CELL CULTURES; DNA; ELECTRON EMISSION; INDIUM 111; IODINE 125; MONTE CARLO METHOD; PERSONNEL DOSIMETRY; PLATINUM 193; PLATINUM 195; RADIATION PROTECTION; RADIONUCLIDE KINETICS; SELENIUM 75; SPERMATOCYTES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BROMINE ISOTOPES; DAYS LIVING RADIOISOTOPES; DOSIMETRY; ELECTRON CAPTURE RADIOISOTOPES; EMISSION; ENERGY TRANSFER; EVEN-ODD NUCLEI; GERM CELLS; HEAVY NUCLEI; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IODINE ISOTOPES; IONIZATION; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MINUTES LIVING RADIOISOTOPES; NUCLEI; NUCLEIC ACIDS; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PLATINUM ISOTOPES; RADIATION EFFECTS; RADIOISOTOPES; SELENIUM ISOTOPES; STABLE ISOTOPES; YEARS LIVING RADIOISOTOPES 560162* -- Radionuclide Effects, Kinetics, & Toxicology-- Animals, Plants, Microorganisms, & Cells