Iron fortification of flour with a complex ferric orthophosphate

Journal Article · Sat Jul 01 00:00:00 EDT 1989 · Am. J. Clin. Nutr.; (United States)

OSTI ID:5603050

Hallberg, L; Rossander-Hulthen, L; Gramatkovski, E

The unexpectedly low bioavailability in humans of elemental iron powder prompted us to search for other Fe compounds suitable for Fe fortification of flour that fulfill the two requirements of insolubility in water (due to high water content of flour) and good bioavailability in humans. Systematic studies of compatibility, solubility, and bioavailability led to this study of a microcrystalline complex ferric orthophosphate (CFOP), Fe/sub 3/H/sub 8/(NH/sub 4/)-(PO/sub 4/)6.6H/sub 2/O, a well-defined compound. This compound was labeled with /sup 59/Fe, and the native Fe in meals was labeled with /sup 55/FeCl3. The ratio of absorbed /sup 59/Fe to absorbed /sup 55/Fe is a direct measure of the fraction of CFOP that joins the nonheme Fe pool and that is made potentially available for absorption. The relative bioavailability of CFOP varied from 30% to 60% when labeled wheat rolls were served with different meals. The CFOP meets practical requirements of an Fe fortificant for flour well, with regard to both compatibility and bioavailability in humans.

• Research Organization: Univ. of Goeteborg (Sweden)
• OSTI ID: 5603050
• Journal Information: Am. J. Clin. Nutr.; (United States), Vol. 50:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
FLOUR
NUTRITION
IRON
BIOLOGICAL AVAILABILITY
BREAD
CEREALS
IRON 55
IRON 59
IRON COMPOUNDS
MAN
PHOSPHATES
SOLUBILITY
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
FOOD
GRASS
INTERMEDIATE MASS NUCLEI
IRON ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LILIOPSIDA
MAGNOLIOPHYTA
MAMMALS
METALS
NUCLEI
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
PLANTS
PRIMATES
RADIOISOTOPES
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550501* - Metabolism- Tracer Techniques