Induction of delayed-type hypersensitivity by the T cell line specific to bacterial peptidoglycans

Journal Article · Tue Dec 01 00:00:00 EST 1987 · J. Immunol.; (United States)

OSTI ID:5602592

Katsuki, M; Kakimoto, K; Kawata, S; Kotani, S; Koga, T

A T cell line specific for the chemically well-defined peptidoglycan of bacterial cell wall, disaccharide tetrapeptide, was established from Lewis rats immunized with the antigen covalently linked to the autologous rat serum albumin. The antigen specificity was examined with various analogues or derivatives of the peptidoglycan. The cell line was reactive to analogues with the COOH-terminal D-amino acid, but least reactive to those with L-amino acid as COOH terminus. Transferring of the T cell line into X-irradiated normal Lewis rats induced delayed-type hypersensitivity in an antigen specific manner.

• Research Organization: Kyushu Univ. School of Dentistry, Fukuoka, Japan
• OSTI ID: 5602592
• Journal Information: J. Immunol.; (United States), Vol. 139:11
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LYMPHOCYTES
SPECIFICITY
RATS
IMMUNE REACTIONS
ALBUMINS
AMINO ACIDS
ANTIGENS
BACTERIA
CELL WALL
GLUCOPROTEINS
RADIATION CHIMERAS
SENSITIVITY
X RADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CHIMERAS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
LEUKOCYTES
MAMMALS
MATERIALS
MICROORGANISMS
MOSAICISM
ORGANIC ACIDS
ORGANIC COMPOUNDS
PROTEINS
RADIATIONS
RODENTS
SACCHARIDES
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals