Mobilization of lead by esters of meso-2,3-dimercaptosuccinic acid

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Journal of Toxicology and Environmental Health; (USA)

OSTI ID:5599978

Singh, P K; Jones, M M; Xu, Z; Gale, G R; Smith, A B; Atkins, L M ^[1]

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1. Vanderbilt Univ., Nashville, TN (USA)

An examination was made of the relative efficacies of 2,3-dimercapto-1-propanol (BAL) and three diesters (CH(SH)COOR)2; DMDMS, R = CH3; DEDMS, R = C2H5; and Di-PDMS, R = CH(CH3)2 of meso-2,3-dimercaptosuccinic acid (DMSA) in mobilizing freshly injected lead from mice. These diesters, like BAL, reduced the lead levels resulting from freshly injected lead in both the soft tissues (liver, kidneys, spleen, and brain) and the bone (tibia). After treatment with the dimethyl (DMDMS), the diethyl (DEDMS), and the diisopropyl (Di-PDMS) esters the lead content of each of the organs was significantly less than that present in the untreated controls. Each of the diesters reduced lead levels in the kidneys, liver, and spleen significantly below those levels found after BAL treatment. The action of the diesters in reducing brain lead levels was comparable to that of BAL. Di-PDMS was the most effective of these compounds and was significantly superior to BAL. Each of the esters was also significantly more effective than BAL in reducing the whole body level of lead.

• OSTI ID: 5599978
• Journal Information: Journal of Toxicology and Environmental Health; (USA), Vol. 27:4; ISSN 0098-4108
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LEAD
TISSUE DISTRIBUTION
SUCCINIC ACID
BIOLOGICAL EFFECTS
ESTERS
LIVER
MICE
STRUCTURE-ACTIVITY RELATIONSHIPS
THIOLS
ANIMALS
BODY
CARBOXYLIC ACIDS
DICARBOXYLIC ACIDS
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
GLANDS
MAMMALS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology