Inhibition of the immune response to experimental fresh osteoarticular allografts
Abstract
The immune response to osteoarticular allografts is capable of destroying the cartilage--a tissue that has antigens on its cells identical to those on the bone and marrow cells. Osteoarticular allografts of the distal femur were performed in rats using various methods to attempt to temporarily inhibit the antibody response. The temporary systemic immunosuppressant regimens investigated were cyclophosphamide, azathioprine and prednisolone, cyclosporine A, and total lymphoid irradiation. The most successful appeared to be cyclosporine A, but significant side effects were observed. To specifically inhibit the immune response in the allograft antigens without systemically inhibiting the entire immune system, passive enhancement and preadministration of donor blood were tried. Neither was as effective as coating the donor bone with biodegradable cements, a method previously found to be successful. Cyclosporine A was investigated in dogs in a preliminary study of medial compartmental knee allografts and was found to be successful in inhibiting the antibody response and in producing a more successful graft; however, some significant side effects were similarly observed.
- Authors:
-
- Univ. of California, Davis, Sacramento (USA)
- Publication Date:
- OSTI Identifier:
- 5599729
- Resource Type:
- Journal Article
- Journal Name:
- Clinical Orthopaedics and Related Research; (USA)
- Additional Journal Information:
- Journal Volume: 243; Journal ID: ISSN 0009-921X
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BONE JOINTS; GRAFTS; IMMUNE REACTIONS; INHIBITION; IMMUNITY; RADIOINDUCTION; ANTIBODY FORMATION; CARTILAGE; DOGS; ENDOXAN; FEMUR; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE DRUGS; IRRADIATION; LYMPHATIC SYSTEM; RATS; TRANSFUSIONS; ALKYLATING AGENTS; ANIMAL TISSUES; ANIMALS; BODY; CONNECTIVE TISSUE; DRUGS; MAMMALS; ORGANS; RODENTS; SKELETON; THERAPY; TISSUES; TRANSPLANTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
Citation Formats
Rodrigo, J J, Schnaser, A M, Reynolds, Jr, H M, Biggart, J.M. 3d., Leathers, M W, Chism, S E, Thorson, E, Grotz, T, and Yang, Q M. Inhibition of the immune response to experimental fresh osteoarticular allografts. United States: N. p., 1989.
Web. doi:10.1097/00003086-198906000-00038.
Rodrigo, J J, Schnaser, A M, Reynolds, Jr, H M, Biggart, J.M. 3d., Leathers, M W, Chism, S E, Thorson, E, Grotz, T, & Yang, Q M. Inhibition of the immune response to experimental fresh osteoarticular allografts. United States. https://doi.org/10.1097/00003086-198906000-00038
Rodrigo, J J, Schnaser, A M, Reynolds, Jr, H M, Biggart, J.M. 3d., Leathers, M W, Chism, S E, Thorson, E, Grotz, T, and Yang, Q M. 1989.
"Inhibition of the immune response to experimental fresh osteoarticular allografts". United States. https://doi.org/10.1097/00003086-198906000-00038.
@article{osti_5599729,
title = {Inhibition of the immune response to experimental fresh osteoarticular allografts},
author = {Rodrigo, J J and Schnaser, A M and Reynolds, Jr, H M and Biggart, J.M. 3d. and Leathers, M W and Chism, S E and Thorson, E and Grotz, T and Yang, Q M},
abstractNote = {The immune response to osteoarticular allografts is capable of destroying the cartilage--a tissue that has antigens on its cells identical to those on the bone and marrow cells. Osteoarticular allografts of the distal femur were performed in rats using various methods to attempt to temporarily inhibit the antibody response. The temporary systemic immunosuppressant regimens investigated were cyclophosphamide, azathioprine and prednisolone, cyclosporine A, and total lymphoid irradiation. The most successful appeared to be cyclosporine A, but significant side effects were observed. To specifically inhibit the immune response in the allograft antigens without systemically inhibiting the entire immune system, passive enhancement and preadministration of donor blood were tried. Neither was as effective as coating the donor bone with biodegradable cements, a method previously found to be successful. Cyclosporine A was investigated in dogs in a preliminary study of medial compartmental knee allografts and was found to be successful in inhibiting the antibody response and in producing a more successful graft; however, some significant side effects were similarly observed.},
doi = {10.1097/00003086-198906000-00038},
url = {https://www.osti.gov/biblio/5599729},
journal = {Clinical Orthopaedics and Related Research; (USA)},
issn = {0009-921X},
number = ,
volume = 243,
place = {United States},
year = {Thu Jun 01 00:00:00 EDT 1989},
month = {Thu Jun 01 00:00:00 EDT 1989}
}