Effect of total lymphoid irradiation on IgE antibody responses in rheumatoid arthritis and systemic lupus erythematosus

Journal Article · Tue Dec 01 00:00:00 EST 1987 · J. Allergy Clin. Immunol.; (United States)

DOI:https://doi.org/10.1016/S0091-6749(87)80268-3· OSTI ID:5592748

Terr, A I; Moss, R B; Strober, S

Thirteen patients with rheumatoid arthritis and four patients with systemic lupus erythematosus and nephritis were treated with total lymphoid irradiation because of severe disease refractory to other forms of treatment. Serum samples before and after irradiation were tested for changes in total serum IgE and for changes in specific IgE antibodies to ryegrass pollen, dust mite, cat dander, and Alternaria. There were no statistically significant changes in total or specific IgE from lymphoid irradiation in these patients. The therapy caused a significant decrease in circulating total lymphocyte and Leu-3 (helper/inducer) T-lymphocyte counts. Therefore, reduction in circulating levels of helper/inducer T cells does not appear to influence preexisting levels of IgE antibodies.

• Research Organization: Stanford Univ. Medical Center, CA
• OSTI ID: 5592748
• Journal Information: J. Allergy Clin. Immunol.; (United States), Vol. 80:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LYMPHATIC SYSTEM
BIOLOGICAL RADIATION EFFECTS
LYMPHOCYTES
CELL PROLIFERATION
RHEUMATIC DISEASES
IMMUNE REACTIONS
ANTIBODIES
IMMUNOGLOBULINS
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BLOOD
BLOOD CELLS
BODY FLUIDS
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ORGANIC COMPOUNDS
PROTEINS
RADIATION EFFECTS
SKELETAL DISEASES
SOMATIC CELLS
560151* - Radiation Effects on Animals- Man