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Title: Biological markers during early pregnancy: trophoblastic signals of the peri-implantation period

The peri-implantation period extends from the time the blastocyst is free in the uterus, through the processes of recognition and attachment, to the beginning of trophoblast differentiation and the interactions between the embryo and the uterine endometrium which initiate establishment of the hemochorial placenta. It is during the peri-implantation period that the embryo and hormonally regulated endometrial cells appear to be most sensitive to factors which introduce risk into the intrauterine environment. There are no markers which can be used practically to assess pregnancy risk during the peri-implantation period of either human or laboratory rodents. Experimental studies, using in vitro laboratory models of differentiating trophoblasst cells, have identified peptide hormone markers of pivotal developmental processes. Exposure of trophoblast during the expression of these processes could have severe and far-reaching effects individually and societally. Human chorionic gonadotropin (hCG) has been used extensively as a marker to assess risk during the early stages of pregnancy. Extrapolation of experimental data indicates how hCG could be used more effectively in analyses of possible cause and effect relationships. The limitations of hCG as a marker for risk during the human peri-implantation period are discussed. Peptide hormones which could serve to assess risk during this criticalmore » period of extraordinary sensitivity to toxic factors are introduced.« less
Authors:
; ; ;
Publication Date:
OSTI Identifier:
5588942
Resource Type:
Journal Article
Resource Relation:
Journal Name: Environ. Health Perspect.; (United States); Journal Volume: 74
Research Org:
Baylor College of Medicine, Houston, TX
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; PREGNANCY; BIOLOGICAL MARKERS; STEROIDS; BIOSYNTHESIS; XENOBIOTICS; BIOLOGICAL EFFECTS; HCG; MICROTUBULES; PEPTIDE HORMONES; PLACENTA; RATS; RISK ASSESSMENT; ANIMALS; CELL CONSTITUENTS; FETAL MEMBRANES; GONADOTROPINS; HORMONES; MAMMALS; MEMBRANES; ORGANIC COMPOUNDS; PITUITARY HORMONES; RODENTS; SYNTHESIS; VERTEBRATES 560300* -- Chemicals Metabolism & Toxicology