The relationship between aminopyrine breath test and severity of liver disease in cirrhosis

Journal Article · Sat Aug 01 00:00:00 EDT 1981 · Am. J. Gastroenterol.; (United States)

OSTI ID:5587547

Morelli, A; Narducci, F; Pelli, M A; Farroni, F; Vedovelli, A

Twenty-two patients with cirrhosis were evaluated by the 2 hr.-(C14)-aminopyrine breath test, the conventional liver tests and two systems for grading the severity of liver disease. Twenty-three patients with noncirrhotic liver disease and 15 controls were also studied. Reduced 14CO2 values were found in 21 of the 22 cirrhotic patients and seven of those had noncirrhotic liver disease associated with severe functional reserve impairment. The values in patients with minor liver diseases or cholestasis were normal. In the cirrhotic patients 2 hr.-(C14)-aminopyrine breath test scores correlated with prothrombin time, retention of bromosulfalein, fasting serum bile acid, albumin, bilirubin, serum aspartate aminotransferase and, above all, with the scores of the two clinical rating systems. The 2 hr.-(C14)-aminopyrine breath test was superior to conventional tests in quantifying the degree of hepatic functional reserve and forecasting the prognosis.

• Research Organization: Clin. Med. Univ., Perugia, Italy
• OSTI ID: 5587547
• Journal Information: Am. J. Gastroenterol.; (United States), Vol. 76:2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
CARBON 14 COMPOUNDS
DIAGNOSTIC USES
LIVER CIRRHOSIS
DIAGNOSIS
ANTIPYRINE
BILE ACIDS
BILIRUBIN
BIOCHEMISTRY
BREATH
CARBON DIOXIDE
LIVER
PATHOLOGY
PATIENTS
ANTIPYRETICS
AZOLES
BODY
CARBON COMPOUNDS
CARBON OXIDES
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHALCOGENIDES
CHEMISTRY
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DRUGS
GLANDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
LABELLED COMPOUNDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PIGMENTS
PYRAZOLES
PYRAZOLINES
PYRROLES
STEROIDS
STEROLS
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550901 - Pathology- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques