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Title: Cellular immune mechanisms in Coxsackievirus group B, type 3 induced myocarditis in Balb/C mice

Coxsackie B viruses are a common cause of viral myocarditis in humans. A murine model of the human disease has been developed using Coxsackievirus group B, type 3 and inbred Balb/c mice. Infection of T lymphocyte deficient mice does not result in significant myocarditis indicating the importance of T cells in this disease. The virus can be isolated from the hearts of T cell deficient and normal mice in equal concentrations. Virus elimination presumably is mediated by virus specific neutralizing antibody induced in both groups. T lymphocytes, natural killer cells and macrophage obtained from normal virus infected mice are all capable of lysing myofibers in vitro. Maximum lysis is obtained with the cytolytic T cells. When these cell populations or Coxsackievirus immune antibody were adoptively transferred into T lymphocyte deficient animals infected with the virus, only animals given T cells developed significant myocarditis.
Authors:
;
Publication Date:
OSTI Identifier:
5586816
Resource Type:
Journal Article
Resource Relation:
Journal Name: Adv. Exp. Med. Biol.; (United States); Journal Volume: 161
Research Org:
Department of Pathology, University of Vermont, Burlington
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; HEART; VIRAL DISEASES; VIRUSES; IMMUNE REACTIONS; LYMPHOCYTES; MICE; RADIATION CHIMERAS; ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CARDIOVASCULAR SYSTEM; CHIMERAS; CONNECTIVE TISSUE CELLS; DISEASES; INFECTIOUS DISEASES; LEUKOCYTES; MAMMALS; MATERIALS; MICROORGANISMS; MOSAICISM; ORGANS; PARASITES; RODENTS; SOMATIC CELLS; VERTEBRATES 550900* -- Pathology