Loss of vascular fibrinolytic activity following irradiation of the liver--an aspect of late radiation damage

Henderson, B W; Bicher, H I; Johnson, R J

doi:10.2307/3576107

Title: Loss of vascular fibrinolytic activity following irradiation of the liver--an aspect of late radiation damage

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Abstract

The vascular fibrinolytic activity, known to originate from the endothelium, was studied histochemically by fibrinolysis autography in liver samples from beagles exposed to radiation treatment. Eighteen to thirty months prior to sacrifice, six dogs received X irradiation (4600 rad in 5 weeks) and three dogs received X irradiation plus aspirin (1 g/kg). Two dogs served as untreated controls. Control livers showed extensive fibrinolytic activity related to large and small vascular structures. The vascular fibrinolytic activity had been lost from all vessels except the major portal branches in five irradiated livers and was severely diminished in three. One irradiated liver appeared to possess normal fibrinolytic activity.

Authors:: Henderson, B W; Bicher, H I; Johnson, R J

Publication Date:: Thu Sep 01 00:00:00 EDT 1983

Research Org.:: Department of Radiation Medicine, Roswell Park Memorial Institute, Buffalo, New York

OSTI Identifier:: 5585850

Resource Type:: Journal Article

Journal Name:: Radiat. Res.; (United States)

Additional Journal Information:: Journal Volume: 95:3

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LIVER; DELAYED RADIATION EFFECTS; ACETYLSALICYLIC ACID; BEAGLES; FEMALES; FIBRINOLYSIS; X RADIATION; ANALGESICS; ANIMALS; ANTIPYRETICS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHEMICAL REACTIONS; DECOMPOSITION; DIGESTIVE SYSTEM; DOGS; DRUGS; ELECTROMAGNETIC RADIATION; GLANDS; HYDROXY ACIDS; IONIZING RADIATIONS; MAMMALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PROTEOLYSIS; RADIATION EFFECTS; RADIATIONS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

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                    Henderson, B W, Bicher, H I, and Johnson, R J. Loss of vascular fibrinolytic activity following irradiation of the liver--an aspect of late radiation damage.  United States: N. p., 1983. 
        Web.  doi:10.2307/3576107.

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                    Henderson, B W, Bicher, H I, & Johnson, R J. Loss of vascular fibrinolytic activity following irradiation of the liver--an aspect of late radiation damage.  United States.  https://doi.org/10.2307/3576107

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                    Henderson, B W, Bicher, H I, and Johnson, R J. 1983.  
        "Loss of vascular fibrinolytic activity following irradiation of the liver--an aspect of late radiation damage".  United States.  https://doi.org/10.2307/3576107.

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@article{osti_5585850,

  title        = {Loss of vascular fibrinolytic activity following irradiation of the liver--an aspect of late radiation damage},

  author       = {Henderson, B W and Bicher, H I and Johnson, R J},

  abstractNote = {The vascular fibrinolytic activity, known to originate from the endothelium, was studied histochemically by fibrinolysis autography in liver samples from beagles exposed to radiation treatment. Eighteen to thirty months prior to sacrifice, six dogs received X irradiation (4600 rad in 5 weeks) and three dogs received X irradiation plus aspirin (1 g/kg). Two dogs served as untreated controls. Control livers showed extensive fibrinolytic activity related to large and small vascular structures. The vascular fibrinolytic activity had been lost from all vessels except the major portal branches in five irradiated livers and was severely diminished in three. One irradiated liver appeared to possess normal fibrinolytic activity.},

  doi          = {10.2307/3576107},

  url          = {https://www.osti.gov/biblio/5585850},
  journal      = {Radiat. Res.; (United States)},
number       = ,

  volume       = 95:3,

  place        = {United States},

  year         = {Thu Sep 01 00:00:00 EDT 1983},

  month        = {Thu Sep 01 00:00:00 EDT 1983}

}

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