Airborne drug levels in a laminar-flow hood
The airborne levels of fluorouracil and cefazolin sodium injections after manipulation of these drug products inside a horizontal laminar-flow hood were measured. The Biotest RCS Centrifugal Air Sampler, generally used to measure microbial levels in air, was adapted with a paper filter to measure drug levels in air. In each of nine trials, five ampuls of fluorouracil were opened in the hood and transferred to empty vials. Likewise, in each of nine trials, 50 vials of cefazolin sodium 1 g were reconstituted and transferred to small-volume i.v. solutions. Drug manipulations were performed between the hood's filter and the Biotest, which was placed inside the hood. Drug collected on the filter in the Biotest was assayed with ultraviolet spectrophotometry after extraction. The range of fluorouracil collected by the Biotest was from 0 to 14 microgram, corresponding to 0-0.07 microgram/liter of sample air. Recovered cefazolin sodium ranged from 28 to 131 microgram, or 0.02-0.11 microgram/liter of sampled air. Following routine manipulation of drug products in a laminar-flow hood, the drug can contaminate, the air flowing over the product.
- OSTI ID:
- 5583840
- Journal Information:
- Am. J. Hosp. Pharm.; (United States), Vol. 38:9
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
54 ENVIRONMENTAL SCIENCES
ANTIBIOTICS
VOLATILITY
FLUOROURACILS
LABORATORIES
WORKING CONDITIONS
AIR POLLUTION
AIR SAMPLERS
FUME HOODS
HOSPITALS
LAMINAR FLOW
ANTI-INFECTIVE AGENTS
ANTIMETABOLITES
AZINES
BUILDINGS
DRUGS
EQUIPMENT
FLUID FLOW
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
LABORATORY EQUIPMENT
MEDICAL CENTERS
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
POLLUTION
PYRIMIDINES
SAMPLERS
URACILS
552000* - Public Health
550600 - Medicine
500200 - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)