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Title: Reproductive toxicity of 2,4-toluenediamine in the rat. 1. Effect on male fertility

Abstract

Effects of 2,4-toluenediamine (TDA) on reproduction in adult male Sprague-Dawley rats were evaluated. Diets containing 0, 0.01 and 0.03% TDA were fed ad libitum to experimental animals for 10 wk. No signs of toxicity were found. Exposure to the high dose resulted in decreased mating frequency and an increase in infertile matings. Light-microscopic examination of the testes revealed reduced numbers of sperm in the seminiferous tubules and cauda epididymides. These results indicate that TDA is capable of reducing fertility and of exerting an inhibitory or toxic effect on spermatogenesis in the rat.

Authors:
; ;
Publication Date:
Research Org.:
Yeshiva Univ., Bronx, NY
OSTI Identifier:
5575097
Resource Type:
Journal Article
Journal Name:
J. Toxicol. Environ. Health; (United States)
Additional Journal Information:
Journal Volume: 16:6
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MALES; FERTILITY; SPERMATOGENESIS; INHIBITION; TDA; TOXICITY; DOSE-RESPONSE RELATIONSHIPS; INGESTION; RATS; REPRODUCTION; TESTES; AMINES; ANIMALS; BODY; CHELATING AGENTS; GAMETOGENESIS; GONADS; INTAKE; MALE GENITALS; MAMMALS; ORGANIC COMPOUNDS; ORGANS; RODENTS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats

Thysen, B, Varma, S K, and Bloch, E. Reproductive toxicity of 2,4-toluenediamine in the rat. 1. Effect on male fertility. United States: N. p., 1985. Web. doi:10.1080/15287398509530786.
Thysen, B, Varma, S K, & Bloch, E. Reproductive toxicity of 2,4-toluenediamine in the rat. 1. Effect on male fertility. United States. https://doi.org/10.1080/15287398509530786
Thysen, B, Varma, S K, and Bloch, E. 1985. "Reproductive toxicity of 2,4-toluenediamine in the rat. 1. Effect on male fertility". United States. https://doi.org/10.1080/15287398509530786.
@article{osti_5575097,
title = {Reproductive toxicity of 2,4-toluenediamine in the rat. 1. Effect on male fertility},
author = {Thysen, B and Varma, S K and Bloch, E},
abstractNote = {Effects of 2,4-toluenediamine (TDA) on reproduction in adult male Sprague-Dawley rats were evaluated. Diets containing 0, 0.01 and 0.03% TDA were fed ad libitum to experimental animals for 10 wk. No signs of toxicity were found. Exposure to the high dose resulted in decreased mating frequency and an increase in infertile matings. Light-microscopic examination of the testes revealed reduced numbers of sperm in the seminiferous tubules and cauda epididymides. These results indicate that TDA is capable of reducing fertility and of exerting an inhibitory or toxic effect on spermatogenesis in the rat.},
doi = {10.1080/15287398509530786},
url = {https://www.osti.gov/biblio/5575097}, journal = {J. Toxicol. Environ. Health; (United States)},
number = ,
volume = 16:6,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 1985},
month = {Tue Jan 01 00:00:00 EST 1985}
}