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Title: Action of T-activin on activity of human natural killer cells in vitro

This paper describes a study of the action of T-activin on activity of human natural killer cells (NKC) in vitro. The K-562 chronic human myeloid leukemia cells, cultured in vitro, used as targets were labeled with /sup 3/H-uridine. The experimental results indicate that T-activin can depress NKC activity but under certain conditions, it can also stimulate NKC. T-activin possesses immunoregulatory properties relative to NKC activity in vitro.
Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
5563541
Resource Type:
Journal Article
Resource Relation:
Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States); Journal Volume: 101:4; Other Information: Translated from Byulleten' Ehksperimental'noj Biologii i Meditsiny; 101: No. 4, 455-457(Apr 1986)
Research Org:
N. I. Pirogov Second Moscow Medical Institute, USSR
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; IMMUNOSUPPRESSIVE DRUGS; BIOLOGICAL EFFECTS; LEUKOCYTES; CELL KILLING; IMMUNE REACTIONS; RADIOIMMUNOASSAY; MAN; MYELOID LEUKEMIA; TUMOR CELLS; BIOLOGICAL FUNCTIONS; DOSE-RESPONSE RELATIONSHIPS; INHIBITION; LABELLING; LYMPHOCYTES; SCINTILLATION COUNTING; THYMUS; TRITIUM COMPOUNDS; URIDINE; ANIMAL CELLS; ANIMALS; AZINES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; COUNTING TECHNIQUES; DISEASES; DRUGS; FUNCTIONS; HEMIC DISEASES; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IMMUNOASSAY; IMMUNOLOGY; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; LEUKEMIA; LYMPHATIC SYSTEM; MAMMALS; MATERIALS; NEOPLASMS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PRIMATES; PYRIMIDINES; RADIOASSAY; RADIOIMMUNOLOGY; RIBOSIDES; SOMATIC CELLS; TRACER TECHNIQUES; URACILS; VERTEBRATES 550301* -- Cytology-- Tracer Techniques; 550901 -- Pathology-- Tracer Techniques