Regulation of isoproterenol-induced salivary gland hyperplasia in young and old mice by substances affecting serotoninergic and dopaminergic systems

Journal Article · Mon Sep 01 00:00:00 EDT 1986 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

DOI:https://doi.org/10.1007/BF00834431· OSTI ID:5563522

Dontsov, V I

This paper studies the effect of substances modulating serotoninergic and dopaminergic structures on induction of hyperplasia of the salivary glands by isoproterenol in young and old mice. /sup 3/H-thymidine was injected into the gland tissue in the experiments. The effect of serotonin and dopamine on isoproterenol-induced proliferation of salivary gland cells and number of activated splenic lymphocytes in old mice is shown. It is found that excitation of serotoninergic structures inhibits, whereas excitation of dopaminergic structures stimulates the response of mice to isoproterenol.

• Research Organization: Institute of Immunology, Moscow, USSR
• OSTI ID: 5563522
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 101:4; Other Information: Translated from Byulleten' Ehksperimental'noj Biologii i Meditsiny; 101: No. 4, 479-480(Apr 1986)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DOPAMINE
METABOLIC ACTIVATION
LYMPHOCYTES
CELL PROLIFERATION
RADIOIMMUNOASSAY
MICE
AGE DEPENDENCE
SALIVARY GLANDS
SEROTONIN
SYMPATHOMIMETICS
BIOLOGICAL EFFECTS
IMMUNE REACTIONS
LABELLING
METABOLISM
MITOTIC INDEX
RESPONSE MODIFYING FACTORS
SPLEEN CELLS
STIMULATION
THYMIDINE
TRITIUM COMPOUNDS
UPTAKE
WEIGHT
AMINES
ANIMAL CELLS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZINES
AZOLES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CONNECTIVE TISSUE CELLS
DRUGS
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
INDOLES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LEUKOCYTES
MAMMALS
MATERIALS
NEUROREGULATORS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PYRIMIDINES
PYRROLES
RADIOASSAY
RADIOIMMUNOLOGY
RADIOPROTECTIVE SUBSTANCES
RIBOSIDES
RODENTS
SOMATIC CELLS
TRACER TECHNIQUES
TRYPTAMINES
VERTEBRATES
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