Inactivation of transcription by UV irradiation of T. brucei provides evidence for a multicistronic transcription unit including a VSG gene
Journal Article
·
· Cell; (United States)
We have used inactivation of transcription by UV irradiation to map transcription units in trypanosomes. The relative inactivation rate of the transcription of mini-exon, 5S, and rRNA genes was inversely proportional to the previously estimated lengths of these transcription units. The telomeric transcription unit containing the gene for variant-specific surface glycoprotein (VSG) 221 was inactivated as a single unit of 60 kb. This long transcription unit comprises at least one other protein-coding gene and yields seven other stable mRNAs. These data thus provide evidence for a multicistronic transcription unit for cellular genes in a eukaryote.
- Research Organization:
- Netherlands Cancer Institute, Antoni van Leeuwenhoekhuis, Amsterdam
- OSTI ID:
- 5556899
- Journal Information:
- Cell; (United States), Vol. 51:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
GENES
TRANSCRIPTION
GLUCOPROTEINS
TRYPANOSOMA
GENETIC RADIATION EFFECTS
INHIBITION
RNA
ULTRAVIOLET RADIATION
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBOHYDRATES
ELECTROMAGNETIC RADIATION
GENETIC EFFECTS
MASTIGOPHORA
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PARASITES
PROTEINS
RADIATION EFFECTS
RADIATIONS
SACCHARIDES
560152* - Radiation Effects on Animals- Animals
GENES
TRANSCRIPTION
GLUCOPROTEINS
TRYPANOSOMA
GENETIC RADIATION EFFECTS
INHIBITION
RNA
ULTRAVIOLET RADIATION
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBOHYDRATES
ELECTROMAGNETIC RADIATION
GENETIC EFFECTS
MASTIGOPHORA
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PARASITES
PROTEINS
RADIATION EFFECTS
RADIATIONS
SACCHARIDES
560152* - Radiation Effects on Animals- Animals