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Title: Pertussis toxins, other antigens become likely targets for genetic engineering

Genetically engineered pertussis vaccines have yet to be fully tested clinically. But early human, animal, and in vitro studies indicate effectiveness in reducing toxic effects due to Bordetella pertussis. The licensed pertussis vaccines consists of inactivated whole cells of the organism. Although highly effective, they have been associated with neurologic complications. While the evidence continues to mount that these complications are extremely rare, if they occur at all, it has affected the public's acceptance of pertussis immunization.
Authors:
Publication Date:
OSTI Identifier:
5556788
Resource Type:
Journal Article
Resource Relation:
Journal Name: JAMA, Journal of the American Medical Association; (United States); Journal Volume: 264:18
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ANTIGENS; AMINO ACID SEQUENCE; TOXINS; GENETIC ENGINEERING; BACTERIA; IMMUNITY; MUTANTS; NERVOUS SYSTEM DISEASES; BIOTECHNOLOGY; DISEASES; MATERIALS; MICROORGANISMS; MOLECULAR STRUCTURE; TOXIC MATERIALS 550400* -- Genetics