Effect of chloroacetic acids on the kidneys
The effects of dichloroacetate (DCA) and trichloroacetate (TCA) administered in drinking water were studied. At high concentrations of either compound, weight loss, or failure to gain weight, was observed. Food consumption was also decreased; both effects were attributed to decreased water consumption. Renal phosphate-dependent glutaminase activity was increased at the highest concentration, and urinary ammonia was also increased. These changes indicated renal adaptation to an acid load. DCA, in pharmacological doses, impairs glucoenogenesis from lactate in part by decreasing lactate availability. Similar tendencies were observed in the present studies; however, female rats showed a biphasic response. At lower DCA concentrations, tissue lactate and plasma glucose concentrations were increased, whereas at higher concentrations of DCA, the expected decreases were observed.
- Research Organization:
- West Virginia Univ. Medical Center, Morgantown
- OSTI ID:
- 5554893
- Journal Information:
- Environ. Health Perspect.; (United States), Vol. 69
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
KIDNEYS
ENZYME ACTIVITY
PHYSIOLOGY
ORGANIC CHLORINE COMPOUNDS
BIOLOGICAL EFFECTS
ACETIC ACID
AMINOPEPTIDASES
BIOLOGICAL PATHWAYS
DIET
DRINKING WATER
RATS
URINE
WEIGHT
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
ENZYMES
HYDROGEN COMPOUNDS
HYDROLASES
MAMMALS
MATERIALS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PEPTIDE HYDROLASES
RODENTS
VERTEBRATES
WASTES
WATER
560300* - Chemicals Metabolism & Toxicology