Incidence and specificity of antibodies to types I, II, III, IV, and V collagen in rheumatoid arthritis and other rheumatic diseases as measured by 125I-radioimmunoassay

Stuart, J M; Huffstutter, E H; Townes, A S; Kang, A H

doi:10.1002/art.1780260703

Title: Incidence and specificity of antibodies to types I, II, III, IV, and V collagen in rheumatoid arthritis and other rheumatic diseases as measured by 125I-radioimmunoassay

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Abstract

Antibodies to human native and denatured types I, II, III, IV, and V collagens were measured using 125I-radioimmunoassay. Mean levels of binding by sera from 30 rheumatoid arthritis patients were significantly higher than those from 20 normal subjects against all of the collagens tested. The relative antibody concentration was higher in synovial fluid than in simultaneously obtained serum. Many patients with gout or various other rheumatic diseases also had detectable anticollagen antibodies. With a few notable exceptions, the majority of the reactivity detected in all patient groups was directed against covalent structural determinants present on all of the denatured collagens, suggesting a secondary reaction to tissue injury.

Authors:: Stuart, J M; Huffstutter, E H; Townes, A S; Kang, A H

Publication Date:: Fri Jul 01 00:00:00 EDT 1983

Research Org.:: Veterans Administration Medical Center, Memphis, Tennessee

OSTI Identifier:: 5551102

Resource Type:: Journal Article

Journal Name:: Arthritis Rheum.; (United States)

Additional Journal Information:: Journal Volume: 26:7

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; COLLAGEN; RADIOIMMUNOASSAY; ANTIBODIES; IODINE 125; RHEUMATIC DISEASES; BETA DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PROTEINS; RADIOASSAY; RADIOISOTOPES; SCLEROPROTEINS; SKELETAL DISEASES; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

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                    Stuart, J M, Huffstutter, E H, Townes, A S, and Kang, A H. Incidence and specificity of antibodies to types I, II, III, IV, and V collagen in rheumatoid arthritis and other rheumatic diseases as measured by 125I-radioimmunoassay.  United States: N. p., 1983. 
        Web.  doi:10.1002/art.1780260703.

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                    Stuart, J M, Huffstutter, E H, Townes, A S, & Kang, A H. Incidence and specificity of antibodies to types I, II, III, IV, and V collagen in rheumatoid arthritis and other rheumatic diseases as measured by 125I-radioimmunoassay.  United States.  https://doi.org/10.1002/art.1780260703

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                    Stuart, J M, Huffstutter, E H, Townes, A S, and Kang, A H. 1983.  
        "Incidence and specificity of antibodies to types I, II, III, IV, and V collagen in rheumatoid arthritis and other rheumatic diseases as measured by 125I-radioimmunoassay".  United States.  https://doi.org/10.1002/art.1780260703.

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@article{osti_5551102,

  title        = {Incidence and specificity of antibodies to types I, II, III, IV, and V collagen in rheumatoid arthritis and other rheumatic diseases as measured by 125I-radioimmunoassay},

  author       = {Stuart, J M and Huffstutter, E H and Townes, A S and Kang, A H},

  abstractNote = {Antibodies to human native and denatured types I, II, III, IV, and V collagens were measured using 125I-radioimmunoassay. Mean levels of binding by sera from 30 rheumatoid arthritis patients were significantly higher than those from 20 normal subjects against all of the collagens tested. The relative antibody concentration was higher in synovial fluid than in simultaneously obtained serum. Many patients with gout or various other rheumatic diseases also had detectable anticollagen antibodies. With a few notable exceptions, the majority of the reactivity detected in all patient groups was directed against covalent structural determinants present on all of the denatured collagens, suggesting a secondary reaction to tissue injury.},

  doi          = {10.1002/art.1780260703},

  url          = {https://www.osti.gov/biblio/5551102},
  journal      = {Arthritis Rheum.; (United States)},
number       = ,

  volume       = 26:7,

  place        = {United States},

  year         = {Fri Jul 01 00:00:00 EDT 1983},

  month        = {Fri Jul 01 00:00:00 EDT 1983}

}

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