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Title: Sequential hemibody and local irradiation with combination chemotherapy for small cell lung carcinoma: a preliminary analysis

Sequential hemibody irradiation (SHB) was integrated with combination chemotherapy and local irradiation (LRT) in the induction and consolidation phases of a therapeutic protocol for small cell lung carcinoma (SCLC). Forty-one previously untreated patients were entered into this program. Among 38 evaluable patients (20 with limited disease (LD) and 18 with extensive disease (ED)), the overall response rate was 63% (90% in LD and 33% in ED patients). The estimated overall survival is 8.1 months. The major toxicity has been myelosuppression - especially thrombocytopenia. The frequency of previously described acute radiation syndromes and radiation pneumonitis associated with hemibody irradiation have been substantially decreased at the current dosage with premedication and shielding techniques.
Authors:
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Publication Date:
OSTI Identifier:
5548340
Resource Type:
Journal Article
Resource Relation:
Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States); Journal Volume: 11:3
Research Org:
Wake Forest Univ., Winston-Salem, NC
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; DIARRHEA; RADIOINDUCTION; IMMUNOSUPPRESSION; PNEUMONITIS; RADIOTHERAPY; SIDE EFFECTS; CARCINOMAS; CHEMOTHERAPY; DOXORUBICIN; ENDOXAN; LUNGS; ONCOVIN; PARTIAL BODY IRRADIATION; PATIENTS; ALKALOIDS; ALKYLATING AGENTS; ANTI-INFECTIVE AGENTS; ANTIBIOTICS; ANTIMITOTIC DRUGS; ANTINEOPLASTIC DRUGS; BODY; DISEASES; DRUGS; EXTERNAL IRRADIATION; IMMUNOSUPPRESSIVE DRUGS; IRRADIATION; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANS; RADIOLOGY; RESPIRATORY SYSTEM; SYMPTOMS; THERAPY 560151* -- Radiation Effects on Animals-- Man; 550603 -- Medicine-- External Radiation in Therapy-- (1980-)