Nuclear-based methods for the study of selenium
- Univ. of Surrey (England)
The essentiality of selenium to the human being and in particular its deficiency state, associated with prolonged inadequate dietary intake, have received considerable attention. In addition, the possible relationship between selenium and cancer and the claim that selenium may possess cancer-prevention properties have focused research effort. It has been observed in a number of studies on laboratory animals that selenium supplementation protects the animals against carcinogen-induced neoplastic growth in various organ sites, reduces the incidence of spontaneous mammary tumors, and suppresses the growth of transplanted tumor cells. In these research programs on the relationship between trace element levels and senile dementia and depression and the elemental changes in blood associated with selenium supplementation in a normal group of volunteers, it became obvious that in addition to establishing normal levels of elements in the population of interest, there was a more fundamental requirement for methods to be developed that would allow the study of the distribution of selenium in the body and its binding sites. The authors propose emission tomography and perturbed angular correlation as techniques worth exploring.
- OSTI ID:
- 5546611
- Report Number(s):
- CONF-880601-; CODEN: TANSA; TRN: 89-026635
- Journal Information:
- Transactions of the American Nuclear Society; (USA), Vol. 56; Conference: American Nuclear Society annual meeting, San Diego, CA (USA), 12-16 Jun 1988; ISSN 0003-018X
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
BIOLOGICAL MATERIALS
EMISSION COMPUTED TOMOGRAPHY
SELENIUM
METABOLISM
AGING
ANIMALS
MAN
NEOPLASMS
RADIOCHEMISTRY
RESEARCH PROGRAMS
UPTAKE
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
ELEMENTS
MAMMALS
MATERIALS
PRIMATES
SEMIMETALS
TOMOGRAPHY
VERTEBRATES
550500* - Metabolism
400700 - Radiochemistry & Nuclear Chemistry