U. S. Environmental Protection Agency's inhalation RFD methodology: Risk assessment for air toxics
The U.S. Environmental Protection Agency (U.S. EPA) has advocated the establishment of general and scientific guidelines for the evaluation of toxicological data and their use in deriving benchmark values to protect exposed populations from adverse health effects. The Agency's reference dose (RfD) methodology for deriving benchmark values for noncancer toxicity originally addressed risk assessment of oral exposures. The paper presents a brief background on the development of the inhalation reference dose (RFDi) methodology, including concepts and issues related to addressing the dynamics of the respiratory system as the portal of entry. Different dosimetric adjustments are described that were incorporated into the methodology to account for the nature of the inhaled agent (particle or gas) and the site of the observed toxic effects (respiratory or extrarespiratory). Impacts of these adjustments on the extrapolation of toxicity data of inhaled agents for human health risk assessment and future research directions are also discussed.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 5545110
- Report Number(s):
- PB-91-163717/XAB; EPA-600/J-90/357
- Resource Relation:
- Other Information: Pub. in Toxicology and Industrial Health, v6 n5 p279-301 Oct 90. Prepared in cooperation with NSI Technology Services Corp., Research Triangle Park, NC
- Country of Publication:
- United States
- Language:
- English
Similar Records
Inhalation reference dose (RfDi): An application of interspecies dosimetry modeling for risk assessment of insoluble particles
Inhalation reference dose (RfDi): An application of interspecies dosimetry modeling for risk assessment of insoluble particles
Related Subjects
AIR POLLUTION
HEALTH HAZARDS
RESPIRATORY SYSTEM
SENSITIVITY
DOSE-RESPONSE RELATIONSHIPS
INHALATION
RISK ASSESSMENT
US EPA
HAZARDS
INTAKE
NATIONAL ORGANIZATIONS
POLLUTION
US ORGANIZATIONS
560300* - Chemicals Metabolism & Toxicology