Bioassay of complex mixtures of indoor air pollutants. Chapter 7
There are several strategies for conducting bioassay studies of indoor air pollutant mixtures. One approach is to generate indoor pollutants from sources under laboratory conditions suitable for human, animal, or in vitro bioassay studies. This approach was used extensively to evaluate tobacco smoke and to a lesser extent for other indoor combustion sources such as kerosene heaters. A second approach is to simulate these complex mixtures by simpler mixtures of pure chemicals which can be used in biological studies. The third approach, which is described in more detail here, is to use bioassays in the direct evaluation of complex mixtures of indoor air pollutants. The mixtures of organics found indoors from combustion sources, building materials, household products and human activities are extremely complex. They consist of thousands of components which are not well characterized or quantified. Many of these mixtures and certain components are potential human carcinogens. The development of short-term bioassays to detect mutagens and potential carcinogens has facilitated studies of complex mixtures including air pollutants and combustion emissions. Chapter 7 will focus on the development and application of bacterial mutagenicity assays to complex mixtures of indoor air pollutants.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 5545089
- Report Number(s):
- PB-91-162560/XAB; EPA-600/D-90/242
- Resource Relation:
- Other Information: Prepared in cooperation with Nordic School of Public Health, Goeteborg (Sweden)
- Country of Publication:
- United States
- Language:
- English
Similar Records
Human exposure to mutagens from indoor combustion sources
Mutagenicity, carcinogenicity, and human cancer risk from indoor exposure to coal and wood combustion in xuan wei, china
Related Subjects
ORGANIC COMPOUNDS
BIOASSAY
CARCINOGEN SCREENING
COMBUSTION PRODUCTS
INDOOR AIR POLLUTION
MIXTURES
MUTAGEN SCREENING
RISK ASSESSMENT
SALMONELLA TYPHIMURIUM
AIR POLLUTION
BACTERIA
DISPERSIONS
MICROORGANISMS
POLLUTION
SALMONELLA
SCREENING
560300* - Chemicals Metabolism & Toxicology