Enhanced suppressor cell activity as a mechanism of immunosuppression by 2,3,7,8-tetrachlorodibenzo-p-dioxin
TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin), a toxic halogenated aromatic hydrocarbon, acts in the body as a cumulative poison. The chronic immunotoxic effects of TCDD were studied in C57B1/6 male mice. Total doses of 100 ..mu..g/kg or greater produced cellular depletion in thymus, spleen, and lymph nodes, and the animals appeared sick. No cellular depletion was seen following 0.4 ..mu..g/kg, and only thymus was affected by 4 and 40 ..mu..g/kg. The antibody response to SRBC and TNP-Brucella abortus was impaired following ..mu..g/kg and the generation of alloantigen-specific cytotoxic T cells (CTL) was sensitive to as little as 0.004 ..mu..g/kg TCDD. In vitro analysis of the mechanism of suppression using limiting dilution techniques showed that TCDD did not deplete the precursors of CTL but generated cells capable of suppressing CTL generation in vitro.
- Research Organization:
- McMaster Univ., Hamilton, Ontario, Canada
- OSTI ID:
- 5543478
- Journal Information:
- Proc. Soc. Exp. Biol. Med.; (United States), Vol. 168:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
HALOGENATED AROMATIC HYDROCARBONS
BIOLOGICAL EFFECTS
ANTIGEN-ANTIBODY REACTIONS
DIOXIN
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
IMMUNOSUPPRESSION
IN VITRO
INJURIES
LYMPH NODES
MICE
SPLEEN
THYMUS
TOXICITY
ANIMALS
AROMATICS
BODY
DATA
HETEROCYCLIC COMPOUNDS
INFORMATION
LYMPHATIC SYSTEM
MAMMALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550900 - Pathology