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Title: Uptake and metabolism of indole compounds by the goldfish pineal organ

Abstract

Indole metabolism was studied in the pineal organ of the goldfish by radioautography and high-performance liquid chromatography. The rate of uptake of tritiated serotonin was rapid in vitro with dense labeling over the photoreceptor cells. Tritiated tryptophan was taken up at a slower rate and the label was distributed evenly over the epithelium. Continual light caused a reduction in the concentration of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) compared to groups exposed to constant darkness both in vivo and in explants, suggesting that these effects are not derived from photoreceptors outside the pineal organ. These data are consistent with the hypothesis that indole metabolism is functionally linked to phototransduction events in the pineal organ of lower vertebrates.

Authors:
Publication Date:
Research Org.:
Loyola Univ. Medical Center, Maywood, IL
OSTI Identifier:
5531375
Resource Type:
Journal Article
Journal Name:
Gen. Comp. Endocrinol.; (United States)
Additional Journal Information:
Journal Volume: 2
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; INDOLES; METABOLISM; UPTAKE; PINEAL GLAND; AUTORADIOGRAPHY; PHOTOSENSITIVITY; BIOLOGICAL LOCALIZATION; GOLDFISH; SEROTONIN; TRYPTOPHAN; AMINES; AMINO ACIDS; ANIMALS; AQUATIC ORGANISMS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZAARENES; AZOLES; BODY; CARBOXYLIC ACIDS; DRUGS; FISHES; GLANDS; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; NEUROREGULATORS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRROLES; RADIOPROTECTIVE SUBSTANCES; SENSITIVITY; SYMPATHOMIMETICS; TRYPTAMINES; VERTEBRATES; 550501* - Metabolism- Tracer Techniques

Citation Formats

McNulty, J A. Uptake and metabolism of indole compounds by the goldfish pineal organ. United States: N. p., 1986. Web. doi:10.1016/0016-6480(86)90195-4.
McNulty, J A. Uptake and metabolism of indole compounds by the goldfish pineal organ. United States. https://doi.org/10.1016/0016-6480(86)90195-4
McNulty, J A. 1986. "Uptake and metabolism of indole compounds by the goldfish pineal organ". United States. https://doi.org/10.1016/0016-6480(86)90195-4.
@article{osti_5531375,
title = {Uptake and metabolism of indole compounds by the goldfish pineal organ},
author = {McNulty, J A},
abstractNote = {Indole metabolism was studied in the pineal organ of the goldfish by radioautography and high-performance liquid chromatography. The rate of uptake of tritiated serotonin was rapid in vitro with dense labeling over the photoreceptor cells. Tritiated tryptophan was taken up at a slower rate and the label was distributed evenly over the epithelium. Continual light caused a reduction in the concentration of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) compared to groups exposed to constant darkness both in vivo and in explants, suggesting that these effects are not derived from photoreceptors outside the pineal organ. These data are consistent with the hypothesis that indole metabolism is functionally linked to phototransduction events in the pineal organ of lower vertebrates.},
doi = {10.1016/0016-6480(86)90195-4},
url = {https://www.osti.gov/biblio/5531375}, journal = {Gen. Comp. Endocrinol.; (United States)},
number = ,
volume = 2,
place = {United States},
year = {Sat Feb 01 00:00:00 EST 1986},
month = {Sat Feb 01 00:00:00 EST 1986}
}