Effect of chlorphentermine on incorporation of (/sup 14/C)choline in the rat lung phospholipids

Journal Article · Sat Mar 01 00:00:00 EST 1986 · Lipids; (United States)

OSTI ID:5528528

Gonmori, K; Morita, T; Mehendale, H M

The effect of chlorphentermine (CP) treatment (50 mg/kg/day, per os (po)) on the incorporation of (/sup 14/C)choline into rat lung phospholipid was studied. Total phospholipid content was increased 2.0-fold and 1.7-fold after seven and /sup 14/ days, respectively, compared with the pair-fed rats. The incorporation of (14C)choline into phosphatidylcholine (PC) was significantly inhibited by either seven or 14 days of CP treatment. Nevertheless, the PC content was significantly increased by day 7 and stayed elevated at day 14 of CP treatment. Choline and phosphorylcholine contents were significantly decreased by the CP treatment. These results suggest that the higher accumulation of PC is due to inhibition of enzymes involved in the hydrolysis of phospholipids rather than to a stimulation of the phospholipid synthesis.

• Research Organization: Univ. of Mississippi Medical Center, Jackson
• OSTI ID: 5528528
• Journal Information: Lipids; (United States), Vol. 3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
AMINES
BIOLOGICAL EFFECTS
CHOLINE
BIOCHEMICAL REACTION KINETICS
PHOSPHOLIPIDS
HYDROLYSIS
CARBON 14 COMPOUNDS
LUNGS
RATS
TRACER TECHNIQUES
ALCOHOLS
AMMONIUM COMPOUNDS
ANIMALS
BODY
CHEMICAL REACTIONS
DECOMPOSITION
DRUGS
ESTERS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LIPIDS
LIPOTROPIC FACTORS
LYSIS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
QUATERNARY COMPOUNDS
REACTION KINETICS
RESPIRATORY SYSTEM
RODENTS
SOLVOLYSIS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques