Neutron diffraction of. cap alpha. ,. beta. and. gamma. cyclodextrins: hydrogen bonding patterns
Cyclodextrins (CD's) are torus-shaped molecules composed of six (..cap alpha..), seven (..beta..) or eight (..gamma..) (1 ..-->.. 4) linked glucoses. ..cap alpha..-CD has been shown to have two different structures with well-defined hydrogen bonds, one tense and the other relaxed. An induced-fit-like mechanism for ..cap alpha..-CD complex formation has been proposed. Circular hydrogen bond networks have also been found for ..cap alpha..-CD due to the energetically favored cooperative effect. ..beta..-CD with a disordered water structure possesses an unusual flip-flop hydrogen bonding system of the type O-H H-O representing an equilibrium between two states; O-H O reversible H-O. ..gamma..-CD with a disordered water structure similar to ..beta..-CD also possesses the flip-flop hydrogen bond. This study demonstrates that hydrogen bonds are operative in disordered systems and display dynamics even in the solid state.
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- Resource Relation:
- Conference: Symposium on conversation in biomolecular stereodynamics III, Albany, NY, USA, 7 Jun 1983
- Research Org:
- Oak Ridge National Lab., TN (USA); Institut Max von Laue - Paul Langevin, 38 - Grenoble (France); Saint Olaf Coll., Northfield, MN (USA); Freie Univ. Berlin (Germany, F.R.). Inst. fuer Kristallographie
- Country of Publication:
- United States
- 59 BASIC BIOLOGICAL SCIENCES; OLIGOSACCHARIDES; CHEMICAL REACTION KINETICS; MOLECULAR STRUCTURE; NEUTRON DIFFRACTION; X-RAY DIFFRACTION; CHELATES; CRYSTAL STRUCTURE; DEUTERIUM COMPOUNDS; GLUCOSE; HYDROLYSIS; LABELLING; VAN DER WAALS FORCES; ALDEHYDES; CARBOHYDRATES; CHEMICAL REACTIONS; COHERENT SCATTERING; COMPLEXES; DECOMPOSITION; DIFFRACTION; HEXOSES; HYDROGEN COMPOUNDS; KINETICS; LYSIS; MONOSACCHARIDES; ORGANIC COMPOUNDS; REACTION KINETICS; SACCHARIDES; SCATTERING; SOLVOLYSIS 550201* -- Biochemistry-- Tracer Techniques
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