Lymphatic flow in humans as indicated by the clearance of /sup 125/I-labeled albumin from the subcutaneous tissue of the leg
Since the removal of albumin from the extracellular space and its return to the vascular compartment is the essential function of the lymphatic system, the rate at which it is removed from the interstitial tissue may be regarded as a means of estimating lymphatic efficiency. An objective measure of lymphatic function can be obtained by monitoring the rate of clearance following injection of /sup 125/I-labeled albumin (RIHSA) from the subcutaneous tissue of a limb. The clearance of /sup 125/I-RIHSA from lower limb was monitored in a group of patients with normal limbs, patients with unilateral edema due to deep vein thrombosis, and patients with bilateral edema due to hypoproteinemia. The mean T1/2 in normal legs was 32.7 hr, compared to 23.7 hr in edematous limbs due to deep vein thrombosis and 19.4 in edematous limbs due to hypoproteinemia. There is a clear-cut difference in clearance rate between edematous and nonedematous limbs. This suggests that lymphatic flow is increased in edema due to venous obstruction and hypoproteinemia.
- Research Organization:
- Department of Surgery, Columbus Hospital, Chicago, Illinois
- OSTI ID:
- 5527752
- Journal Information:
- J. Surg. Res.; (United States), Vol. 35:2
- Country of Publication:
- United States
- Language:
- English
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IODINE 125
BLOOD-PLASMA CLEARANCE
LYMPHATIC SYSTEM
DYNAMIC FUNCTION STUDIES
ALBUMINS
EDEMA
FEMALES
LABELLED COMPOUNDS
MALES
NUTRITIONAL DEFICIENCY
PATIENTS
SKIN
THROMBOSIS
TRACER TECHNIQUES
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CLEARANCE
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROTEINS
RADIOISOTOPES
SYMPTOMS
VASCULAR DISEASES
551001* - Physiological Systems- Tracer Techniques