Interspecies comparison of the metabolism and dosimetry of inhaled mixed oxides of plutonium and uranium
- Lovelace Respiratory Research Institute, Albuquerque, NM (United States)
Three studies were conducted to provide information on the biological fate, distribution of radiation doses among tissues, and implications for potential health consequences of an inhalation exposure to mixed-oxide nuclear fuel materials. In each study, Fischer-344 rats, beagle dogs, and cynomolgus monkeys inhaled one of three aerosols: 750{degrees}C calcined mixed oxides of UO{sub 2} and PuO{sub 2}, 1750{degrees}C sintered (U,Pu)O{sub 2}, or 850{degrees}C calcined {open_quotes}pure{close_quotes} PuO{sub 2}. These materials were collected from glove-box enclosures immediately after industrial processing of mixed-oxide fuel materials. Lung retention, tissue distribution, and mode of excretion of {sup 238-240}Pu, {sup 241}Am, and uranium (when present) were quantified by radiochemical analysis of tissue and excreta samples from animals sacrificed at selected times to 6.5 yr after inhalation exposure.
- OSTI ID:
- 552651
- Report Number(s):
- CONF-971125-; ISSN 0003-018X; TRN: 98:001858
- Journal Information:
- Transactions of the American Nuclear Society, Vol. 77; Conference: 1997 American Nuclear Society (ANS) winter meeting, Albuquerque, NM (United States), 16-20 Nov 1997; Other Information: PBD: 1997
- Country of Publication:
- United States
- Language:
- English
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