Toxic congener-specific analysis of PCBs: assessment of toxicity in equivalents of TCDD

Journal Article · Thu Jan 01 00:00:00 EST 1987 · Anal. Lett.; (United States)

DOI:https://doi.org/10.1080/00032718708082590· OSTI ID:5523328

Olafsson, P G; Bryan, A M

High resolution capillary gas chromatographic analysis of the polychlorobiphenyls (PCBs) present in snapping turtle eggs, provided quantitative data on selected toxic congeners. The concentrations of these congeners have been converted into equivalent toxic concentrations of 2,3,7,8-tetrachloro-p-dibenzodioxin (TCDD). The toxic equivalent factors (TEFs), necessary to effect this transformation were derived from EC/sub 50/ values (half the concentration of the toxic congener required to produce the maximum effect) for aryl hydrocarbon hydroxylase (AHH) induction associated with the corresponding toxic PCB congener or isomer. Summation of the resulting toxic equivalents provided a composite assessment of the toxicity of the PCB mixture in terms of an equivalent concentration of TCDD.

• Research Organization: Xenobiotics Corp., Albany, NY
• OSTI ID: 5523328
• Journal Information: Anal. Lett.; (United States), Vol. 20:11
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
CHLORINATED AROMATIC HYDROCARBONS
GAS CHROMATOGRAPHY
TOXICITY
EGGS
QUANTITATIVE CHEMICAL ANALYSIS
CAPILLARIES
EXPERIMENTAL DATA
TURTLES
ANIMALS
AROMATICS
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CHEMICAL ANALYSIS
CHROMATOGRAPHY
DATA
HALOGENATED AROMATIC HYDROCARBONS
INFORMATION
NUMERICAL DATA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
REPTILES
SEPARATION PROCESSES
VERTEBRATES
400102* - Chemical & Spectral Procedures