Cytogenetic analysis of the 2B1-2-2B9-10 region of the X chromosome of Drosophila melanogaster. V. Changes in the pattern of polypeptide synthesis in salivary glands caused by mutations located in the 2B5 puff
The authors have investigated the role of the 2B5 puff in the synthesis of ecdysone-inducible proteins. They showed that in mutants for the overlapping complementation complex (occ) located in the 2B5 puff the synthesis of these proteins is impaired: in mutants 1t336 and 1t366 to a lesser extent and in mutant t143 to a greater extent. Similarly to the deletion of the 2B5 puff, mutation t435 completely blocks the synthesis of ecdysone-inducible proteins. An increase in the dose of the 2B5 puff leads to an increase in the level of synthesis of two ecdysone-inducible polypeptides, for which evidence is available that they are encoded in the region of another ecdysone puff. The results obtained, together with the findings that the tissues of larvae mutant for the occ locus are not sensitive to the action of 20-hydroxy ecdysone and that the normal course of development of ecdysone-dependent puffing is impaired in the chromosomes of salivary glands of these mutants, suggest the presence of a key regulatory role of the 2B5 puff in metamorphosis.
- Research Organization:
- Institute of Cytology and Genetics, Novosibirsk, USSR
- OSTI ID:
- 5520142
- Journal Information:
- Sov. Genet. (Engl. Transl.); (United States), Vol. 21:8; Other Information: Translated from Genetika; 21: No. 8, 1282-1289(Aug 1985)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
DROSOPHILA
SALIVARY GLANDS
POLYPEPTIDES
BIOSYNTHESIS
RADIOASSAY
X CHROMOSOME
CHROMOSOMAL ABERRATIONS
MUTAGENESIS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
GENETIC MAPPING
LABELLING
LARVAE
LEUCINE
TRITIUM COMPOUNDS
AMINO ACIDS
ANIMALS
ARTHROPODS
BODY
CARBOXYLIC ACIDS
CHROMOSOMES
DIPTERA
FLIES
FRUIT FLIES
GLANDS
HETEROCHROMOSOMES
INSECTS
INVERTEBRATES
KINETICS
LABELLED COMPOUNDS
MAPPING
MUTATIONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
PROTEINS
REACTION KINETICS
SYNTHESIS
550401* - Genetics- Tracer Techniques