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Title: Subclinical effects of chronic increased lead absorption--a prospective study. Part IV. Evaluation of heme synthesis effects

The effects of lead exposure on heme synthesis in workers with subclinical responses and in controls were evaluated. delta-Aminolevulinic acid dehydratase (ALA-d) correlated significantly with blood lead levels in the control group but not with those in the exposed group. Free erythrocyte protoporphyrin correlated significantly with blood lead levels in the exposed group but not with those in the controls and was found to be a good indicator of blood lead history among exposed persons. Hemoglobin values determined at initial employment were not statistically different from those determined during the baseline test for a group of 12 workers with a maximum blood lead level of 86 micrograms/100 ml during their exposure history. The effect such heme inhibition may have on other body functions is uncertain.
Authors:
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Publication Date:
OSTI Identifier:
5510062
Resource Type:
Journal Article
Resource Relation:
Journal Name: J. Occup. Med.; (United States); Journal Volume: 24:2
Research Org:
School of Public Health, UCLA
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HEME; BIOSYNTHESIS; INHIBITION; LEAD; ABSORPTION; BIOLOGICAL EFFECTS; HEMOGLOBIN; KETO ACIDS; OXIDOREDUCTASES; PERSONNEL; PROTOPORPHYRINS; CARBOXYLIC ACIDS; ELEMENTS; ENZYMES; GLOBIN; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; METALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PIGMENTS; PORPHYRINS; PROTEINS; SYNTHESIS 560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)