Reduction of cerebral glucose utilization by the HIV envelope glycoprotein Gp-120
Journal Article
·
· Experimental Neurology; (United States)
- Neuropharmacology Laboratory, National Institute on Drug Abuse, Baltimore, MD (USA)
Gp-120 is a glycoprotein constituent of the human immunodeficiency virus (HIV) envelope. The effects of gp-120 on cerebral glucose utilization in rats were studied by the quantitative 2-deoxy-D-(1-14C) glucose method. Intracerebroventricular injection of gp-120 significantly reduced glucose utilization in the lateral habenula and the suprachiasmatic nucleus and decreased the global cerebral metabolic rate for glucose. The findings suggest that gp-120 and closely related peptides can alter neuronal function, thereby contributing to the sequelae of HIV infection.
- OSTI ID:
- 5509387
- Journal Information:
- Experimental Neurology; (United States), Vol. 112:2; ISSN 0014-4886
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
CEREBRAL CORTEX
METABOLISM
GLUCOSE
GLYCOPROTEINS
BIOCHEMICAL REACTION KINETICS
AIDS
AUTORADIOGRAPHY
CARBON 14 COMPOUNDS
DOSE-RESPONSE RELATIONSHIPS
NERVES
RATS
TRACER TECHNIQUES
ALDEHYDES
ANIMALS
BODY
BRAIN
CARBOHYDRATES
CARBON COMPOUNDS
CENTRAL NERVOUS SYSTEM
CEREBRUM
DISEASES
HEXOSES
IMMUNE SYSTEM DISEASES
INFECTIOUS DISEASES
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PROTEINS
REACTION KINETICS
RODENTS
SACCHARIDES
VERTEBRATES
VIRAL DISEASES
550501* - Metabolism- Tracer Techniques
CEREBRAL CORTEX
METABOLISM
GLUCOSE
GLYCOPROTEINS
BIOCHEMICAL REACTION KINETICS
AIDS
AUTORADIOGRAPHY
CARBON 14 COMPOUNDS
DOSE-RESPONSE RELATIONSHIPS
NERVES
RATS
TRACER TECHNIQUES
ALDEHYDES
ANIMALS
BODY
BRAIN
CARBOHYDRATES
CARBON COMPOUNDS
CENTRAL NERVOUS SYSTEM
CEREBRUM
DISEASES
HEXOSES
IMMUNE SYSTEM DISEASES
INFECTIOUS DISEASES
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PROTEINS
REACTION KINETICS
RODENTS
SACCHARIDES
VERTEBRATES
VIRAL DISEASES
550501* - Metabolism- Tracer Techniques