Reduction of cerebral glucose utilization by the HIV envelope glycoprotein Gp-120

Journal Article · Wed May 01 00:00:00 EDT 1991 · Experimental Neurology; (United States)

DOI:https://doi.org/10.1016/0014-4886(91)90073-L· OSTI ID:5509387

Kimes, A S; London, E D; Szabo, G; Raymon, L; Tabakoff, B ^[1]

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1. Neuropharmacology Laboratory, National Institute on Drug Abuse, Baltimore, MD (USA)

Gp-120 is a glycoprotein constituent of the human immunodeficiency virus (HIV) envelope. The effects of gp-120 on cerebral glucose utilization in rats were studied by the quantitative 2-deoxy-D-(1-14C) glucose method. Intracerebroventricular injection of gp-120 significantly reduced glucose utilization in the lateral habenula and the suprachiasmatic nucleus and decreased the global cerebral metabolic rate for glucose. The findings suggest that gp-120 and closely related peptides can alter neuronal function, thereby contributing to the sequelae of HIV infection.

• OSTI ID: 5509387
• Journal Information: Experimental Neurology; (United States), Vol. 112:2; ISSN 0014-4886
• Country of Publication: United States
• Language: English

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