Estimation of relative regional neuroreceptor concentration by PET or SPECT: Theoretical comparisons of using a single late image or a late plus early image

Journal Article · Wed Sep 01 00:00:00 EDT 1993 · IEEE Transactions on Medical Imaging (Institute of Electrical and Electronics Engineers); (United States)

DOI:https://doi.org/10.1109/42.241877· OSTI ID:5507123

Zeeberg, B R; Kim, Hee Joung; Reba, R C ^[1]

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1. George Washington Univ., Washington, DC (United States). Dept. of Radiology

The potential for using a single SPECT or PET image to estimate quantitatively the relative regional neuroreceptor concentration was previously analyzed both theoretically and experimentally. The success of this approach depends upon acquiring the image at a time when changes in the regional radioactivity localization are much more sensitive to changes in receptor concentration than to changes in delivery. Using the binding of [[sup 11]C]carfentanil to the opiate receptor as a model, the authors have applied a computer simulation approach to determine the joint and marginal probability distributions for the ipsilateral/contralateral ratio of receptor concentrations and delivery. The authors have studied the effect, upon the probability distributions, of (1) the values of the sensitivities to receptor and delivery, (2) the selection of a particular operational procedure for interpreting the observed ipsilateral and contralateral radioactivity localizations, and (3) the inclusion of radioactivity localizations at an early time point in addition to those at the later time point. The authors have found that the probability distributions depend upon the sensitivities for both delivery and receptor. Incorporation of data at an early time point results in a significant sharpening of the probability distributions. There is an insignificant effect of subtraction of the radioactivity localization in a control region.

• DOE Contract Number: FG05-88ER60649
• OSTI ID: 5507123
• Journal Information: IEEE Transactions on Medical Imaging (Institute of Electrical and Electronics Engineers); (United States), Vol. 12:3; ISSN 0278-0062
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
EMISSION COMPUTED TOMOGRAPHY
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COMPARATIVE EVALUATIONS
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SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
EVALUATION
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