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Title: Free bone graft reconstruction of irradiated facial tissue: Experimental effects of basic fibroblast growth factor stimulation

Abstract

A study was undertaken to evaluate the potential utility of basic fibroblast growth factor in the induction of angiogenesis and osseous healing in bone previously exposed to high doses of irradiation. Thirty New Zealand rabbits were evaluated by introducing basic fibroblast growth factor into irradiated mandibular resection sites either prior to or simultaneous with reconstruction by corticocancellous autografts harvested from the ilium. The fate of the free bone grafts was then evaluated at 90 days postoperatively by microangiographic, histologic, and fluorochrome bone-labeling techniques. Sequestration, necrosis, and failure to heal to recipient osseous margins was observed both clinically and histologically in all nontreated irradiated graft sites as well as those receiving simultaneous angiogenic stimulation at the time of graft placement. No fluorescent activity was seen in these graft groups. In the recipient sites pretreated with basic fibroblast growth factor prior to placement of the graft, healing and reestablishment of mandibular contour occurred in nearly 50 percent of the animals. Active bone formation was evident at cortical margins adjacent to the recipient sites but was absent in the more central cancellous regions of the grafts.

Authors:
; ; ; ; ;  [1]
  1. Plastic Surgery Section, Indiana University Medical Center (USA)
Publication Date:
OSTI Identifier:
5505792
Resource Type:
Journal Article
Journal Name:
Plastic and Reconstructive Surgery; (United States)
Additional Journal Information:
Journal Volume: 88:1; Journal ID: ISSN 0032-1052
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; GROWTH FACTORS; BIOLOGICAL FUNCTIONS; JAW; BIOLOGICAL RADIATION EFFECTS; SKELETON; GRAFTS; FIBROBLASTS; HEALING; OSTEORADIONECROSIS; RABBITS; WOUNDS; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; BODY; CONNECTIVE TISSUE CELLS; DISEASES; INJURIES; LOCAL RADIATION EFFECTS; MAMMALS; MITOGENS; NECROSIS; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PROTEINS; RADIATION EFFECTS; RADIATION INJURIES; RECOVERY; SKELETAL DISEASES; SKULL; SOMATIC CELLS; TRANSPLANTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Eppley, B L, Connolly, D T, Winkelmann, T, Sadove, A M, Heuvelman, D, and Feder, J. Free bone graft reconstruction of irradiated facial tissue: Experimental effects of basic fibroblast growth factor stimulation. United States: N. p., 1991. Web. doi:10.1097/00006534-199107000-00001.
Eppley, B L, Connolly, D T, Winkelmann, T, Sadove, A M, Heuvelman, D, & Feder, J. Free bone graft reconstruction of irradiated facial tissue: Experimental effects of basic fibroblast growth factor stimulation. United States. https://doi.org/10.1097/00006534-199107000-00001
Eppley, B L, Connolly, D T, Winkelmann, T, Sadove, A M, Heuvelman, D, and Feder, J. 1991. "Free bone graft reconstruction of irradiated facial tissue: Experimental effects of basic fibroblast growth factor stimulation". United States. https://doi.org/10.1097/00006534-199107000-00001.
@article{osti_5505792,
title = {Free bone graft reconstruction of irradiated facial tissue: Experimental effects of basic fibroblast growth factor stimulation},
author = {Eppley, B L and Connolly, D T and Winkelmann, T and Sadove, A M and Heuvelman, D and Feder, J},
abstractNote = {A study was undertaken to evaluate the potential utility of basic fibroblast growth factor in the induction of angiogenesis and osseous healing in bone previously exposed to high doses of irradiation. Thirty New Zealand rabbits were evaluated by introducing basic fibroblast growth factor into irradiated mandibular resection sites either prior to or simultaneous with reconstruction by corticocancellous autografts harvested from the ilium. The fate of the free bone grafts was then evaluated at 90 days postoperatively by microangiographic, histologic, and fluorochrome bone-labeling techniques. Sequestration, necrosis, and failure to heal to recipient osseous margins was observed both clinically and histologically in all nontreated irradiated graft sites as well as those receiving simultaneous angiogenic stimulation at the time of graft placement. No fluorescent activity was seen in these graft groups. In the recipient sites pretreated with basic fibroblast growth factor prior to placement of the graft, healing and reestablishment of mandibular contour occurred in nearly 50 percent of the animals. Active bone formation was evident at cortical margins adjacent to the recipient sites but was absent in the more central cancellous regions of the grafts.},
doi = {10.1097/00006534-199107000-00001},
url = {https://www.osti.gov/biblio/5505792}, journal = {Plastic and Reconstructive Surgery; (United States)},
issn = {0032-1052},
number = ,
volume = 88:1,
place = {United States},
year = {Mon Jul 01 00:00:00 EDT 1991},
month = {Mon Jul 01 00:00:00 EDT 1991}
}